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Benzodiazepine withdrawal syndrome - Wikipedia

Much of this work is focused on dopamine receptor signaling pathways that regulate drug intake and craving responses. Our studies suggest that alterations in cyclic AMP-dependent protein phosphorylation, and downstream regulation of gene expression, contributes to escalating drug intake and a propensity for relapse by differentially altering the sensitivity of D1 and D2 dopamine receptors in direct and indirect pathways of the ventral striatum. In addition, our studies suggest that drug-induced neuroplasticity at excitatory synapses in the mesolimbic dopamine system can facilitate drug craving through specific interactions with dopamine receptors and their regulation of motivated behavior. Many of these neurobiological changes can be reversed or normalized by “extinction training” a behavioral learning procedure that may be useful in treating drug addiction seeking behavior and the propensity for relapse. Current studies are using optogenetic laser stimulation approaches to mimic or reverse addiction-related neuroplasticity in anatomically distinct pathways in addicted rodents.

We are also using microarray profiling and deep sequencing technology to search for novel and enduring changes in gene expression that persist or arise during withdrawal from chronic drug use. It is important to identify these changes because the propensity for relapse remains high even after months of abstinence. We have found that long-term drug withdrawal is associated with an up-regulation in endogenous opiate systems that enhance the propensity for relapse. Overall, the laboratory conducts conceptually based, hypothesis-driven research into the basic neurobiology of motivated behavior and its disruption during the addiction process, but potential pharmacological, neurostimulation and behavior-based treatments are discovered.

Antidepressant withdrawal syndromes : Evidence supporting the cholinergic overdrive hypothesis

AB - The authors present case examples of the various antidepressant withdrawal syndromes. Substantial evidence supports the contention that these syndromes result from cholinergic overdrive; thus, they may have a common pathophysiological basis. Even paradoxical reactions on antidepressant withdrawal, such as mania, are consistent with the cholinergic overdrive hypothesis. If the cholinergic overdrive hypothesis is accepted, antidepressant withdrawal phenomena lend support to the cholinergic-adrenergic hypothesis of affective illness. The cholinergic overdrive hypothesis is both of considerable heuristic value and is further testable by the study of the tonic and phasic aspects of sleep and neuroendocrine parameters in the withdrawal state.

Opiate Withdrawal Relief Supplements, Medications …

19/12/2017 · On Oct 8, 2009, Lorenzo Magnani published the chapter: Creative Abduction and Hypothesis Withdrawal in the book: Models of Discovery and Creativity.

The authors present case examples of the various antidepressant withdrawal syndromes. Substantial evidence supports the contention that these syndromes result from cholinergic overdrive; thus, they may have a common pathophysiological basis. Even paradoxical reactions on antidepressant withdrawal, such as mania, are consistent with the cholinergic overdrive hypothesis. If the cholinergic overdrive hypothesis is accepted, antidepressant withdrawal phenomena lend support to the cholinergic-adrenergic hypothesis of affective illness. The cholinergic overdrive hypothesis is both of considerable heuristic value and is further testable by the study of the tonic and phasic aspects of sleep and neuroendocrine parameters in the withdrawal state.

N2 - The authors present case examples of the various antidepressant withdrawal syndromes. Substantial evidence supports the contention that these syndromes result from cholinergic overdrive; thus, they may have a common pathophysiological basis. Even paradoxical reactions on antidepressant withdrawal, such as mania, are consistent with the cholinergic overdrive hypothesis. If the cholinergic overdrive hypothesis is accepted, antidepressant withdrawal phenomena lend support to the cholinergic-adrenergic hypothesis of affective illness. The cholinergic overdrive hypothesis is both of considerable heuristic value and is further testable by the study of the tonic and phasic aspects of sleep and neuroendocrine parameters in the withdrawal state.

Surviving wheat withdrawal | Dr. William Davis

This review proposes a unifying hypothesis that females experience greater rewarding effects of nicotine and more intense stress produced by withdrawal than males.

The Withdrawal Hypothesis
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