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Thespread of the tumor was somewhat reminiscent of a lymphoma.

A limb-salvage procedure, involving a wide resectionand a total knee endoprosthesis replacement, was performed in May2012. Examination of the resection specimen showed a soft,light-yellow (or gray), gelatinous tumor measuring 13 cm along thelong axis of the femur and 6 cm transversely. The tumor wascentered in the distal part of the femur, with involvement of thesurrounding soft tissues. A central hemorrhagic and necrotic areacontained serosanguineous fluid, with an abundant local bloodsupply (). No intra-articularextension was observed and there was no indication of regionalmetastasis on dissection of the popliteal fossa lymph nodes. Thepatient’s postoperative course was uneventful.

Tumor Endoprosthesis Revision Rates Increase ..

When analyzing the infection of tumor endoprostheses, one should take into account the rarity of the condition, the wide variety of independent variables, and the diversity in the definition of infection. Compared with conventional arthroplasty, tumor endoprosthesis is less frequent, and the accompanying independent variables much more diverse. In addition, the definition of deep infection might be different from that in conventional arthroplasty. The guidelines of the Centers for Disease Control and Prevention [] define deep infection or organ/space surgical site infection as infection that occurs within 1 year of surgery if an implant is in place, appears to be related to the operation, and involves deep soft tissues. However, in many previous studies, infections occurring more than 12 months after initial tumor endoprosthesis operations were interpreted as surgical site infections [,,]. In order to overcome these bottlenecks, we selected a multicenter approach. In addition, we strictly defined deep infection at the beginning of the study to avoid confusion in data interpretation.

Read papers from the keyword Tumor endoprosthesis with Read by QxMD.

The use of cemented fixation for tumor endoprostheses obviates the requirement for osseointegration, and chemotherapy does not need to be

A limb-salvage procedure, involving a wide resectionand a total knee endoprosthesis replacement, was performed in May2012. Examination of the resection specimen showed a soft,light-yellow (or gray), gelatinous tumor measuring 13 cm along thelong axis of the femur and 6 cm transversely. The tumor wascentered in the distal part of the femur, with involvement of thesurrounding soft tissues. A central hemorrhagic and necrotic areacontained serosanguineous fluid, with an abundant local bloodsupply (). No intra-articularextension was observed and there was no indication of regionalmetastasis on dissection of the popliteal fossa lymph nodes. Thepatient’s postoperative course was uneventful.

In the present study, we used multiinstitutional retrospective surveillance data to analyze the conditions of tumor endoprosthesis infection around the knee, the most frequent tumor endoprosthesis infection site []. We focused on clinical symptoms, culture results, treatment modalities, the status of prosthesis and limb salvage, and underlying factors that might influence the characteristics of deep infections.

Deep infection in tumor endoprosthesis around the …

The use of cemented fixation for tumor endoprostheses obviates the requirement for osseointegration, and chemotherapy does not need to be

Tumor endoprostheses have several advantages, including reliability, durability, modularity, and relatively wide availability which have led to them becoming the reconstruction method of choice in most centers [1,2] .

In the past, protocols incorporated delays of initiation or resumption of chemotherapy after limb salvage surgery to improve tumor endoprosthesis survival.

However, complications compromising the longevity of tumor endoprostheses remain a significant problem.
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Osteosarcoma | Surgery with tumor endoprosthesis implantation

We analyzed clinical data of 57 patients with deep infections involving tumor endoprostheses around the knee enrolled from the Japanese Musculoskeletal Oncology Group. Profile of clinical presentation including time between surgery and infection, initial symptoms/blood tests and microbial cultures was evaluated. In addition pre-, intra-, and postoperative clinical factors influencing clinical presentation and treatment outcomes of infections were analyzed.

Tumor endoprosthesis in malignant bone tumors

The incidence of endoprosthesis failure has been well studied, but few studies have described the clinical characteristics of deep infection in tumor prostheses. This study aimed to analyze the characteristics of deep infection in tumor endoprostheses around the knee.

Tumor Endoprosthesis Revision Rates Increase With …

N2 - Background. Although deep infection remains one of the most diffi cult complications to manage in the treatment of musculoskeletal tumor reconstructed with an endoprosthesis, limited information with respect to its incidence and risk factors has been reported. Methods. This multicenter, retrospective, uncontrolled study reviewed the medical records of 82 patients who underwent reconstruction with an endoprosthesis or temporary spacer for bone-immature patients after resection of malignant bone tumor around the knee. Risk factors for deep infection and the impact of deep infection on prosthesis survival and oncological outcomes were analyzed. Deep infection was defi ned according to the Centers for Disease Control and Prevention (CDC) guidelines with minor modifi cation. Results. Deep infection occurred in 14 cases (17%), identifi ed at a mean of 10.9 months (range

Functional assessment of endoprosthesis in the …

Background. Although deep infection remains one of the most diffi cult complications to manage in the treatment of musculoskeletal tumor reconstructed with an endoprosthesis, limited information with respect to its incidence and risk factors has been reported. Methods. This multicenter, retrospective, uncontrolled study reviewed the medical records of 82 patients who underwent reconstruction with an endoprosthesis or temporary spacer for bone-immature patients after resection of malignant bone tumor around the knee. Risk factors for deep infection and the impact of deep infection on prosthesis survival and oncological outcomes were analyzed. Deep infection was defi ned according to the Centers for Disease Control and Prevention (CDC) guidelines with minor modifi cation. Results. Deep infection occurred in 14 cases (17%), identifi ed at a mean of 10.9 months (range

PubMed/NCBI - National Center for Biotechnology Information

AB - Background. Although deep infection remains one of the most diffi cult complications to manage in the treatment of musculoskeletal tumor reconstructed with an endoprosthesis, limited information with respect to its incidence and risk factors has been reported. Methods. This multicenter, retrospective, uncontrolled study reviewed the medical records of 82 patients who underwent reconstruction with an endoprosthesis or temporary spacer for bone-immature patients after resection of malignant bone tumor around the knee. Risk factors for deep infection and the impact of deep infection on prosthesis survival and oncological outcomes were analyzed. Deep infection was defi ned according to the Centers for Disease Control and Prevention (CDC) guidelines with minor modifi cation. Results. Deep infection occurred in 14 cases (17%), identifi ed at a mean of 10.9 months (range

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