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triglyceride - definition - What is
Biosynthesis of cholesterol is directly regulated by the cholesterol levels present, though the homeostatic mechanisms involved are only partly understood. A higher intake from food leads to a net decrease in endogenous production, while lower intake from food has the opposite effect. The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (Sterol Regulatory Element Binding Protein 1 and 2). In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP-cleavage activating protein) and Insig-1. When cholesterol levels fall, Insig-1 dissociates from the SREBP-SCAP complex, allowing the complex to migrate to the Golgi apparatus, where SREBP is cleaved by S1P and S2P (site 1/2 protease), two enzymes that are activated by SCAP when cholesterol levels are low. The cleaved SREBP then migrates to the nucleus and acts as a transcription factor to bind to the SRE (Sterol regulatory element) of a number of genes to stimulate their transcription. Among the genes transcribed are the LDL receptor and HMG-CoA reductase. The former scavenges circulating LDL from the bloodstream, whereas HMG-CoA reductase leads to an increase of endogenous production of cholesterol. An excess of cholesterol can build up in the bloodstream and accumulates on the walls of arteries. This build up is what can lead to clogged ateries and eventually to heart attacks and strokes.
Increased exercise and reduced carbohydrate consumption ameliorate one potential cause of insulin overproduction to help maintain sensible triglyceride levels. Triglyceride levels are also reduced by from fish, seed oil and other sources. Recommendation in the U.S. is that one ingest up to 3 grams a day of such oils. In Europe the recommendation is for up to 2 grams. However, omega-3 consumption should be balanced with , ideally in a ω-6/ω-3 ratio between 1:1 and 4:1 (i.e., no more than four grams omega-6 for every one of omega-3). Daily ingestion of omega-6 fatty acids, more than 1 gram of (i.e., a mega-dose of vitamin B-3) and may also help improve triglyceride levels.
lipid biosynthesis drives the progression" of ..
There is a world-wide trend to believe that lower total cholesterol levels tend to correlate with lower atherosclerosis event rates (though many studies refute this idea). Due to this reason, cholesterol has become a very large focus for scientific researchers trying to determine the proper amount of cholesterol needed in a healthy diet. However, the primary association of atherosclerosis with cholesterol has always been specifically with cholesterol transport patterns, not total cholesterol per se. For example, total cholesterol can be low, yet made up primarily of small LDL and small HDL particles and atheroma growth rates are high. In contrast, however, if LDL particle number is low (mostly large particles) and a large percentage of the HDL particles are large (HDL is actively reverse transporting cholesterol), then atheroma growth rates are usually low, even negative, for any given total cholesterol concentration. These effects are further complicated by the relative concentration of aymmetric dimethylarginin (ADMA) in the endothelium, since ADMA down-regulates production of nitric oxide, a relaxant of the endothelium. Thus, high levels of ADMA, associated with high oxidized levels of LDL pose a heightened risk factor for vascular disease.
The seeds of (Cruciferae), a cabbage-like annual herb cultivated in Northern Europe, contain an oil high in erucic acid (about 56%). The seed oil of () contains triglycerides with over 98% fatty acids over 20 carbon atoms.
It helps to lower LDL cholesterol and triglyceride in the blood, ..
Multiple human trials utilizing HMG-CoA reductase inhibitors or statins, have repeatedly confirmed that changing lipoprotein transport patterns from unhealthy to healthier patterns significantly lower cardiovascular disease event rates, even for people with cholesterol values currently considered low for adults; However, no statistically significant mortality benefit has been derived to date by lowering cholesterol using medications in asymptomatic people, i.e., no heart disease, no history of heart attack, etc.
Thus, vernolic acid (cis-12,13-epoxy-cis-9-octadecenoic acid) is found in , and .
Curiously, acetic acid was shown to be a component of natural triglycerides in some plant species.
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ELOVL6 Gene - GeneCards | ELOV6 Protein | ELOV6 …
Several studies in animal models have shown that erucic acid may have detrimental effects on cardiovascular physiology, therefore, a low erucic acid oil is now produced and can be used safely in the food industry.
Soya, corn, sunflower and walnut oils are very rich in one , linoleic acid (18:2n-6) while rapeseed, walnut and soya oils are precious sources of one , linolenic acid (18:3n-3).
The seed oils of watercress () and Honesty ( annua) have relatively high proportions of C22:1 (38-48%) and C24:1(22-25%) fatty acids in their triglyceride molecules, these peculiarities make them potentially suitable for production of high-temperature lubricants and engineering nylons.
ACACA Gene - GeneCards | ACACA Protein | ACACA …
(Severe) pain under right side of ribs Liver/gallbladder cleanses helpSymptoms - Metabolic Unexplained high/moderate unexplained/mild unexplained fevers or unexplained fevers that hit hard Having a high/having a moderate/having a slight feverSymptoms - Skin - General Lighter/paler skin colorSymptoms - Urinary Dark urine color Conditions that suggest Gallbladder Disease: Digestion Dyspepsia / Poor DigestionLab Values Elevated Triglycerides Gallstone formation does not correlate with blood cholesterol levels, but persons with low HDL cholesterol (the so-called good cholesterol) levels or high triglyceride levels are at increased risk.
Is Agribusiness Making You Sick? – Return Of Kings
This reduced flow leads to an increase in stone formation.[Ann Allergy 26: pp.83-7, 1968)]Hormones Low Progesterone or Estrogen DominanceLab Values Elevated LDL/HDL Ratio Gallstone formation does not correlate with blood cholesterol levels, but persons with low HDL cholesterol (the so-called good cholesterol) levels or high triglyceride levels are at increased risk.
Full text of "NEW" - Internet Archive
In the human body, high levels of triglycerides in the bloodstream have been linked to , and, by extension, the risk of and . However, the relative negative impact of raised levels of triglycerides compared to that of LDL:HDL ratios is as yet unknown. The risk can be partly accounted for by a strong inverse relationship between triglyceride level and HDL-cholesterol level.
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