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Propofol Synthesis | Sulfuric Acid | Chemical Reactions

All studies followed similar procedures except that during anesthesia studies, subjects were removed from the scanner following the 6-min transmission scan for induction of anesthesia; they were subsequently repositioned in the scanner at the previously determined coordinates. This was done to ensure safety because: (1) induction may be associated with involuntary head movements which could result in head trauma if subjects were left inside the scanner, and (2) it was necessary to have immediate access to the airway in the event that propofol caused acute respiratory or cardiac complications during induction. Propofol was not administered until we had confirmation of successful L-[1-11C]leucine synthesis. Therefore, to minimize delays and maximize activity available for injection, while still allowing adequate time for safe induction of anesthesia, we obtained positioning and transmission scans prior to anesthesia administration; this necessitated removal of the subjects during induction.

The full synthesis of Propofol step by step, ..
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In addition, propofol was shown to downregulate the phosphoinositide 3‑kinase (PI3K)/Akt/GSK‑3β signaling pathway and inhibit glycogen synthesis in hepatocytes.

Documents Similar To Propofol Synthesis

1=Synthesis of Propofol}} {{de|1=synthese von Propofol}} |Source = ..
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Here's another example of a synthesis reaction:

H2 + O2 ---> H2O2
This happens to be a reaction that can never take place.

Memory function as assessed by the HVLT-R was unaffected by 100–110 min period of propofol anesthesia. Numerous studies have examined the effects of propofol on memory function during anesthesia (; ) and most reports conclude that even with evidence of some awareness during sedation, memory of the events is not preserved. We found that anesthesia with propofol had no effect on the memory consolidation of a task learned 1–1.5 h prior to induction. Assuming that protein synthesis is required for memory consolidation, our finding that rCPS was invariant with propofol is therefore consistent with the results of memory testing (HVLT-R). However, it may be that consolidation had already taken place in the interval (~ 1.5 h) between training and propofol administration. A study in which 20 words were repeated to subjects immediately before a 76 min propofol infusion showed that recall tested about 4 h later was on average 12% (), well below the recall in our study.

Commercial Manufacturing of Propofol: Simplifying …

Nov 11, 2016 · Propofol Problems So in my earlier thread "At home aromatic substitutions" I expressed my desire to perform this synthesis …
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Propofol is an anesthetic agent often used to facilitate acquisition of diagnostic imaging studies in children and adults who, because of their age and/or disease might be unable to remain motionless for prolonged periods of time. The use of propofol anesthesia is particularly helpful in patients with neurodevelopmental disorders that are characterized by impairment in language and cognitive functions which make imaging studies in awake patients rather challenging or simply impossible (; ). Because some of these imaging studies are used to characterize anatomic and metabolic parameters over the course of the progression of neurodevelopmental disorders, it is important to know the effects of anesthetic agents on the variables studied. Here we examined the effect of a commonly used anesthetic agent, propofol, on cerebral protein synthesis in healthy human volunteers. Our finding that propofol anesthesia has no significant effect on rCPS in healthy young men is of critical importance for future applicability of the L-[1-11C]leucine PET method in the study of subjects with neurodevelopmental and neurodegenerative disorders.

We had anticipated that rCPS might be affected by anaesthesia as it has been shown to suppress protein synthesis in extracerebral tissues (; ; ). Halothane affects translation initiation and synthesis of secreted and retained proteins in a dose dependent manner in the liver (). Studies in yeast indicate that one of the factors affecting halothane-induced inhibition of translation initiation is the phosphorylation of eIF2α (). Propofol anaesthesia has been shown to suppress protein synthesis in skeletal muscle, a response that can be partially reversed by administration of amino acids (). Effects of anaesthetics on core body temperature may also influence protein synthesis (; ). In contrast, little is known about the in vivo effects of anaesthetics on cerebral protein synthesis. Earlier animal studies have reported generalized decreases in rCPS with barbiturate anaesthesia (; ), but methodological issues may limit interpretation of these studies. A study with the autoradiographic [1-14C]leucine method found small decreases in rCPS (1–11%) () with thiopental anaesthesia. Nevertheless, this is the first study to evaluate the effect of propofol anaesthesia on cerebral protein synthesis in normal human volunteers.

Here we examined the effect of a commonly used anesthetic agent, propofol, on cerebral protein synthesis in healthy human volunteers
Photo provided by Flickr
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