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19894-97-4 Synthesising (+)-PERILLYL ALCOHOL …
Mills JJ, Chari RS, Boyer IJ, Gould MN andJirtle RL: Induction of apoptosis in liver tumors by themonoterpene perillyl alcohol. Cancer Res. 55:979–983.1995.
Agents under study include: epigallocatechin gallate (EGCG), a green tea catechin with antioxidant and sunscreen activity, as well as UVB signal transduction blocking activity; perillyl alcohol, a monoterpene derived from citrus peel that inhibits Ras farnesylation; difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase and polyamines; retinoids that target retinoid X receptors and AP-1 activity; and nonsteroidal anti-inflammatory agents that inhibit cylooxygenase and prostaglandin synthesis.
LAVENDER: Uses, Side Effects, Interactions and …
da Fonseca CO, Simão M, Lins IR, CaetanoRO, Futuro D and Quirico-Santos T: Efficacy of monoterpene perillylalcohol upon the survival rate of patients with recurrentglioblastoma. J Cancer Res Clin Oncol. 137:287–293. 2011.
Phillips LR, Malspeis L and Supko JG:Pharmacokinetics of active drug metabolites after oraladministration of perillyl alcohol, an investigationalantineoplastic agent, to the dog. Drug Metab Dispos. 23:676–680.1995.
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Ripple GH, Gould MN, Stewart JA, TutschKD, Arzoomanian RZ, Alberti D, Feierabend C, Pomplun M, Wilding Gand Bailey HH: Phase I clinical trial of perillyl alcoholadministered daily. Clin Cancer Res. 4:1159–1164. 1998.
Bailey HH, Attia S, Love RR, Fass T,Chappell R, Tutsch K, Harris L, Jumonville A, Hansen R, Shapiro GRand Stewart JA: Phase II trial of daily oral perillyl alcohol (NSC641066) in treatment-refractory metastatic breast cancer. CancerChemother Pharmacol. 62:149–157. 2008. : :
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Ripple GH, Gould MN, Arzoomanian RZ,Alberti D, Feierabend C, Simon K, Binger K, Tutsch KD, Pomplun M,Wahamaki A, Marnocha R, Wilding G and Bailey HH: Phase I clinicaland pharmacokinetic study of perillyl alcohol administered fourtimes a day. Clin Cancer Res. 6:390–396. 2000.
Synthesis and Antiproliferative Effects of Amino ..
Liu G, Oettel K, Bailey H, Ummersen LV,Tutsch K, Staab MJ, Horvath D, Alberti D, Arzoomanian R, RezazadehH, McGovern J, Robinson E, DeMets D and Wilding G: Phase II trialof perillyl alcohol (NSC 641066) administered daily in patientswith metastatic androgen-independent prostate cancer. Invest NewDrugs. 21:367–372. 2003. : :
Inhibition of ubiquinone and cholesterol synthesis by …
Haag JD and Gould MN: Mammary carcinomaregression induced by perillyl alcohol, a hydroxylated analog oflimonene. Cancer Chemother Pharmacol. 34:477–483. 1994. : :
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4–6 Although the mechanism of d -limonene and perillyl alcohol of inhibiting tumor cell growth is unclear, it has been proposed that inhibition of farnesyl transferase might be one of their action targets.
Enhancement of sterol synthesis by the ..
Shi W and Gould MN: Induction ofcytostasis in mammary carcinoma cells treated with the anticanceragent perillyl alcohol. Carcinogenesis. 23:131–142. 2002. : :
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Stark MJ, Burke YD, McKinzie JH, Ayoubi ASand Crowell PL: Chemotherapy of pancreatic cancer with themonoterpene perillyl alcohol. Cancer Lett. 96:15–21. 1995. : :
Dry Beans and Peas (Legumes) - AICR
Perillyl alcohol (POH) is a naturally occurringmonoterpene found in the essential oils of cherry, lemongrass,gingergrass, cranberry, perilla, mint, lavender, sage, wildbergamot, caraway and celery seeds (,). Ithas been shown that POH exerts antitumor activity against malignanttumor cells and . POH inhibits thegrowth of various types of malignant tumor cells through blockade of proliferation, angiogenesis and migration, andinduction of differentiation and apoptosis (–).Regarding the antiproliferative activity of POH, this monoterpeneis reported to cause cell cycle arrest at the G1 phase throughdownregulation of cyclin D1 and upregulation ofp21 in murine mammary transformed cells orthrough upregulation of both p21 andp27 in human pancreatic adenocarcinoma cells(,). Moreover, POH significantly inhibitsthe growth of mammary and liver tumors in rodent models (,).Based on these preclinical data, clinical studies using POH havecommenced in patients with advanced malignancies. However, twophase II studies in patients with refractory metastatic breastcancer and metastatic androgen-independent prostate cancer reportedthat no objective responses were observed (,).On the other hand, a recent clinical study showed that intranasaladministration of POH increased the overall survival of patientswith recurrent glioblastoma ().
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