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A new synthesis of pantethine and some analogues thereof

A pantothenic acid derivative called pantethine has been reported by anumber of investigators to have a cholesterol lowering effect. Pantethine is actually two molecules of pantetheine joined by adisulfide bond (chemical bond between two molecules of sulfur). In the synthetic pathway of coenzyme A (CoA), pantethine is closer to CoA thanpantothenic acid, and is the functional component of CoA and acyl carrier proteins. Several studies found doses of 900 mg of pantethinedaily (300 mg, three times daily) to be significantly more effective than placebo in lowering total cholesterol and triglyceride levels in the blood of both diabetic and non-diabetic individuals. Pantethine was also found to lower cholesterol and triglyceride levels in diabetic patients on hemodialysis without adverse side effects. The low side effect profile of pantethine was especially attractive for hemodialysis patients because of the increased risk of drug toxicity in patients with renal (kidney) failure. Pantethine is not a vitamin; it is a derivative of pantothenic acid. The decision to use pantethine to treat elevated blood cholesterol or triglycerides should be made in collaboration with a qualified health care provider, who can provide appropriate follow up.

5 Powerful Pantethine Benefits - University Health News
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The acyl-carrier protein requires pantothenic acid in the form of phosphopantetheine for its activity as an enzyme. Both CoA and the acyl-carrier protein are required for the synthesis of fatty acids. Fatty acids are a component of some lipids, which are fat molecules essential for normal physiological function. Among these essential fats are sphingolipids, which are a component of the myelin sheath that enhances nerve transmission, and phospholipids in cell membranes.

5 Powerful Pantethine Benefits Pantethine, ..

| A synthesis of pantethine (II) has been evolved by the condensation of D(-)-pantolactone with di-(2-N-β-alanylamidoethyl) disulphide
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While the exact mechanism of Pantethine is in normalizing parameters associated with dyslipidemia is not clear, clinical studies have proven that when pantethine is added to cultured cells, it causes an 80% inhibition in cholesterol synthesis, most likely inhibiting the activity of HMG-CoA reductase.



Reducing or Eliminating Acne with Pantethine and L Carnitine

Using the modified Leung B5 protocol with Pantethine 750 mg with 250 mg of L Carnitine three times a day, we have noted excellent success rates in reducing or eliminating acne. An added advantage is a good cosmetic result with smaller pore size and smoother skin. The vitamins are safe with no adverse side effects noted.

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A College Student with Acne

A college student under my care was making preparations for her upcoming wedding when she noticed some new acne lesions on her face. We immediately began the Pantethine and L-Carnitine. Her acne cleared up immediately, and she was quite pleased. By now, we have a number of satisfied patients who have used this program to clear up acne. I myself have used the program and can report that it works quite well.

Also Used for Weight Loss

Since this anti-acne regimen is essentially a fat burning protocol, it is also useful for weight loss as noted in this .

No Adverse Side Effects

Unlike Accutane which may have serious adverse side effects. vitamin B5 have little or no adverse side effects.

Acetyl CoA Important for Cholesterol and Steroid Biosynthesis

Acetyl CoA is the first in the body's synthesis of Cholesterol. Cholesterol is then used to make all steroidal hormones. Many of the steroidal hormones are made by the adrenal gland, so it is very logical that B5 deficiency can result in a syndromes called adrenal failure, or the inability to synthesis steroidal hormones such as Cortisol. See my previous article on for more information about this syndrome.



is an autoimmune disease with no known cause first described in 1851. A blood test for anti-nuclear antibodies is diagnostic. However, a number of features of Lupus suggest a link with steroid hormone synthesis.

For example, there is a well know tendency for lupus to flare up under certain conditions in which there is a greater demand for steroidal hormone biosynthesis, such as puberty, and pregnancy. Females are more affected than males by a ratio of ten to one. Lupus preferentially affects females because they have greater demands for hormone production than do males. These lupus flares seem to correlate with demand for higher levels of hormones. Production of higher hormone levels could deplete the stores of precursor molecules for production of these hormones. The first such precursor molecule is acetyl CoA, so a deficiency in acetyl CoA could be the culprit.


Low Hormone Levels in Lupus

Another feature of female lupus patients is that when hormone levels are measured, they tend to run low. Irregular menstrual cycles and absent menses is common among lupus patients.

Pantethine As A Detox Supplement » The Candida Diet

[1954] New Synthesis of Pantethine and Some Analogues thereof. 1171 A New Synthesis of Pantethine and Some Analogues thereof. By R. E. BOWMAN and J. F. CAVALLA.
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Pantethine As A Detox Supplement
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