Call us toll-free

Quick academic help

Don't let the stress of school get you down! Have your essay written by a professional writer before the deadline arrives.

Calculate the price

Pages:

275 Words

$19,50

Synthesis of functionalized 2-oxindoles by …

A novel method for the synthesis of 3,3-difluoro-2-oxindoles was developed. 2-Bromo-2,2-difluoro-N-phenylacetamide was prepared from neat simple aromatic amines with ethyl bromodifluoroacetate. Reflux of the product in CH3CN with CH3I for 24 h gave 2-bromo-2,2-difluoro-N-methyl-N-phenylacetamide in 75%~90% yields. In the presence of 3.0 chemometric number sodium formaldehyde sulfoxylate, this key intermediate undergoes intramolecular radical cyclization in aqueous solution(N,N-dimethylformamide/H2O) and affords the final product 3,3-difluoro-1-methylindolin-2-ones in 53%~72% yields. This method can be performed in aqueous solution from commercially available and affordable starting materials without any metal catalysts. It shows potential in industrial production of 3,3-difluoro-2-oxindoles.

The Martinet dioxindole synthesis is utilized in the preparation of oxindole derivatives

This review describes the latest synthetic methods found in the literature for the construction of complex natural products containing the spiro[pyrrolidine-3,3′-oxindole] ring system and other oxindoles that are closely related. The spirooxindole system is the central structure of many different types of natural products and synthetic drugs, which are associated with various biological activities. The well-known interest that these compounds inspire in academia, as well as in industry together with our efforts toward the total synthesis of sarpagine-/macroline-related oxindoles inspired us to review this topic. Herein, the strategies used by other expert groups in the field of synthetic organic chemistry and their results are presented in a critical way. The examples were selected on the basis of the elegant way chemists resolved their synthetic challenges. Many other excellent syntheses of complex oxindoles can be found in the literature, but were not included due to the limit in the length of this manuscript.

Synthesis of oxindoles by radical cyclisation - [PDF …

Metal-Free Synthesis of 3,3-Difluoro-2-Oxindoles

3,3-Disubstituted oxindoles are an important family of biologically active heterocycles, and numerous synthetic methodologies have been developed for their synthesis over past decades. Recently, the tandem radical cyclization of -arylacrylamides has provided a new powerful approach to access various diversely functionalized 3,3-disubstituted oxindoles. This review will highlight recent advances in this field as well as applications in natural product synthesis in terms of different types of radical source. Particular emphases have also been placed on working models.

3,3-Disubstituted oxindoles are an important family of biologically active heterocycles, and numerous synthetic methodologies have been developed for their synthesis over past decades. Recently, the tandem radical cyclization of -arylacrylamides has provided a new powerful approach to access various diversely functionalized 3,3-disubstituted oxindoles. This review will highlight recent advances in this field as well as applications in natural product synthesis in terms of different types of radical source. Particular emphases have also been placed on working models.1 Introduction2 Tandem Radical Addition/Cyclization Reaction of -Arylacrylamides with Carbon Radicals2.1 Aryl Radicals2.2 Alkyl Radicals2.3 Fluorine-Containing Carbon Radicals2.4 Acyl Radicals3 Tandem Radical Addition/Cyclization Reaction of -Arylacrylamides with Heteroatom Radicals3.1 Phosphonyl Radicals3.2 Sulfur Radicals3.3 Nitrogen Radicals4 Conclusion and Perspective

Synthesis of 3,3-Disubstituted 2-Oxindoles by …

A novel method for the synthesis of 3,3-difluoro-2-oxindoles was developed

The synthesis of functionalized oxindoles and benzofuranones via oxidation of 2-BMIDA indoles and benzofurans, respectively, is described. Interconversion of boron species (BMIDA→BF3K) was necessary to enable oxidation and overcome boronic acid stability issues associated with a difficult BMIDA hydrolysis. Overall, a robust process was developed that allowed access to a small library of oxindole and benzofuranone products and facilitated the step-efficient synthesis of biologically active compounds containing the oxindole pharmaco­phore.

The synthesis of functionalized oxindoles and benzofuranones via oxidation of 2-BMIDA indoles and benzofurans, respectively, is described. Interconversion of boron species (BMIDA→BF3K) was necessary to enable oxidation and overcome boronic acid stability issues associated with a difficult BMIDA hydrolysis. Overall, a robust process was developed that allowed access to a small library of oxindole and benzofuranone products and facilitated the step-efficient synthesis of biologically active compounds containing the oxindole pharmaco­phore.

Catalytic asymmetric synthesis of hetero-substituted oxindoles
Order now
  • UNMATCHED QUALITY

    As soon as we have completed your work, it will be proofread and given a thorough scan for plagiarism.

  • STRICT PRIVACY

    Our clients' personal information is kept confidential, so rest assured that no one will find out about our cooperation.

  • COMPLETE ORIGINALITY

    We write everything from scratch. You'll be sure to receive a plagiarism-free paper every time you place an order.

  • ON-TIME DELIVERY

    We will complete your paper on time, giving you total peace of mind with every assignment you entrust us with.

  • FREE CORRECTIONS

    Want something changed in your paper? Request as many revisions as you want until you're completely satisfied with the outcome.

  • 24/7 SUPPORT

    We're always here to help you solve any possible issue. Feel free to give us a call or write a message in chat.

Order now
  • You submit your order instructions

  • We assign an appropriate expert

  • The expert takes care of your task

  • We send it to you upon completion

Order now
  • 37 684

    Delivered orders

  • 763

    Professional writers

  • 311

    Writers online

  • 4.8/5

    Average quality score

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order