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Synthesis of 1,4-Naphthoquinone Derivatives …

Vitamin K3 is also known as menadione. It has the chemical name 2-methyl-1, 4 naphthoquinone. It’s compound formula is C11H8O2. It is a bright yellow crystalline powder that is soluble in vegetable oils. It is a synthetic analogue that acts as a provitamin. It is used as a vitamin K supplement. Menadione is necessary for the production of prothrombin and other blood clotting factors. It can also help regulate the calcification of bones. Too large a dose of vitamin K3 can cause serious problems, and even death.

“Synthesis of Two Naphthoquinone Antibiotics Pentalongin and Psychorubrin.”  11 (1999): 1881–1883.

Vitamin K2, also known as menaquinone, has the chemical name 2-methyl-3-difarnesyl-1, 4-naphthoquinone. It’s compound formula is C41H56O2. It is a naturally occurring vitamin that is found in various large intestine bacteria. Vitamin K2 helps activate vitamin K dependent proteins responsible for healthy tissue and bone. It helps to activate the protein, osteocalcin, which is required to bind calcuim to the mineral matix, which strengthens the bones. It is found in sources such as butter, eggs, cow liver, cheese and fermented products.

1,4-Naphthoquinone | Sigma-Aldrich

Vitamin K1 is found in green vegetables such as spinach, broccoli, avocado, brussel sprouts, kale and cabbage, cauliflower, kiwi, alfalfa and some vegetable oils, or it can be made synthetically. It can be given orally to treat prothrombin deficiency that may result from anticoagulant drugs.

Vitamin K1 is a form of vitamin K. It has the chemical name 2-methyl-3phytyl-1, 4-naphthoquinone. It’s compound formula is C31,H46,O2. It is a clear, yellow to amber, viscous liquid that is odorless or almost odorless. It is one of the oil-soluble vitamins found in green plants and prepared synthetically. It is soluble in chloroform, but insoluble in water. It is used as a prothrombinogenic agent. Vitamin K1 was named phylloquinone because it is an indirect product of photosynthesis in plant leaves.

Search results for 1,4-Naphthoquinone at Sigma-Aldrich

Naphthoquinone has an odor similar to benzoquinone. It is slightly soluble in cold water and petroleum ether. It is soluble in most polar organic solvents. Naphthoquinone derivatives possess anti-bacterial and anti-tumor properties. 1,4-naphthoquinone derivatives occur naturally in the form of vitamin K.

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