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Percutaneous absorption of salicylic acid.
Application of teething gels containing salicylic acid induced intoxication (Paynter & Alexandre, 1979). 9.2.4 Eye contact 9.2.5 Parenteral exposure 9.2.6 Other
Salicylate inhibits the conversion of arachidonic acid to the unstable endoperoxide intermediate PG G2, which is catalyzed by the enzyme cyclo oxygenase.
Disturbances of acid-base equilibrium in salicylate intoxication.
The loss of buffering capacity and the effects of salicylate on carbohydrate, lipid and protein metabolism lead to the development of a metabolic acidosis or, more commonly in practice, a mixed acid-base disturbance (Proudfoot & Brown, 1969; Meredith & Vale, 1981; Proudfoot, 1983).
The uricosuric activity of phenylbutazone, probenecide and sulphinpyrazone is strongly antagonized by salicylate and maybe completely diminished by small doses due to decreased tubular reabsorption of uric acid (Insel, 1996).
was to synthesis salicylic acid from Wintergreen ..
Acid-base disturbances are usually mixed in mild to moderate salicylate poisoning (Proudfoot & Brown, 1969; Proudfoot, 1983). 8.3.3 Haematological analyses 8.3.4 Interpretation of biomedical investigations
In patients with significant acidosis and in patients who ingest multiple doses or sustained release preparations, the Done nomogram will tend to underestimate the severity of salicylate intoxication (Todd et al., 1981).
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Synthesis of salicylic acid - Sciencemadness Wiki
Salicylic acid is also used in the form of paint and in the form of collodion basis (10 to 17%) or as a plaster (20 to 50%) to destroy warts and corns.
alexleyenda's synthesis from methyl salicylate
The presenting signs of chronic salicylate poisoning can include metabolic acidosis, hypoglycemia, lethargy, coma and fits (English et al., 1996). 9.2.2 Inhalation 9.2.3 Skin exposure
Under Reflux- Synthesis of Salicylic Acid from Wintergreen Oil ..
Life threatening salicylate poisoning caused by percutaneous absorption of salicylic acid (10% ointment) in a 7-year-old boy with ichthyosis vulgaris was reported (German et al., 1996).
from methyl salicylate and salicylic acid ..
Salicylic acid (SA) signaling plays an important role in local and systemic acquired resistance. Expression and activity of pathogenesis-related proteins are stimulated by the accumulation of SA, conferring resistance to pathogens. SA can be synthesized via the phenylpropanoid route or the isochorismate pathway and metabolized to form SA-glucoside and SA glucose-ester through glucosylation, and methyl salicylate through methylation. This summary focuses on genes involved in SA biosynthesis, metabolism, and signaling. SA and jasmonic acid (JA) crosstalk has an important role in regulating induced defense against pathogens by exerting antagonistic effects. Therefore, results on crosstalk between SA and JA are also shortly reviewed. Further investigation on the molecular aspect of SA and JA antagonism, elucidating how these pathways are linked to each other, and how they resolve the complexity of host-pathogen interaction will provide a better understanding on SA signaling and plant defense.
Organic Chemistry Exp 4: Synthesis of Salicylic Acid …
Cigarette smoking, chronic salicylate ingestion, metabolic acidosis and the presence of neurological symptoms and signs on admission are strong risk factors for the subsequent development of pulmonary oedema.
The synthesis of methyl salicylate: Amine diazotization
The concentration of salicylate causing this effect is high, and their relationship to the antirheumatic efficacy of salicylates is yet to be determined. 9.4.12 Metabolic 18.104.22.168 Acid-base disturbances
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