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Patent US3379757 - Malic acid synthesis - Google Patents

Rashid A, Pizer ES, Moga M, et al:Elevated expression of fatty acid synthase and fatty acid syntheticactivity in colorectal neoplasia. Am J Pathol. 150:201–208.1997.

Malic acid is an organic compound with the molecular formula C 4 H 6 O 5

French researchers found that a leucine -supplemented diet restored a more youthful pattern of muscle-protein breakdown and synthesis to elderly rats.
is sometimes used to prevent herpes virus outbreaks although the research on this topic has shown mixed results.
and cysteine are the only sulfur-containing proteinogenic amino acids.

Patent US5210295 - Preparation of malic acid - Google Patents

Lipogenesis occurs both in liver and adipose tissuesresulting in the synthesis of fatty acids fromacetyl CoA synthesized by glycolysis (). Acetyl CoA is then carboxylatedby ACC forming malonyl CoA. Malonyl CoA and acetyl CoA are furtherprocessed by fatty acid synthase (FAS) in palmitic acid, which isthen transformed by Elvol6 into stearic acid (). SCD1 catalyzes the formation ofpalmitoleoyl-CoA and oleoyl-CoA from palmitoyl-CoA andstearoyl-CoA, respectively (),which are preferentially transformed in triglycerides for storagein adipose tissue or phospholipids for membrane formation ().

Methionine plays a role in cysteine, carnitine and taurine synthesis, lecithin production, the synthesis of phosphatidylcholine and other phospholipids. Methionine is an amino acid that has antioxidant properties.

Search results for malic acid at Sigma-Aldrich

Others studies point for a role of SCD1 in cancerprogression and metastasis (). It was shown that MUFA content in cholesterol esters isassociated with higher death rate in cancer patients () while elevated levels of oleic acidwere observed in breast cancers with metastasis (), suggesting an increased activity ofSCD1. Low content of stearic acid (SCD1 substrate) inphosphatodylcholine were also measured in breast tumors associatedwith subsequent metastasis (). Inbreast adipose tissues, no difference in MUFA content was observedbetween benign tumors and normal tissues, but a positivecorrelation was observed between MUFA concentration and metastasis(). Alteration of SFA/MUFAratio in breast tumors does not reflect the dietary intake ofpatients but rather the change in fatty acid metabolism in cells() underlying a role for synthesized MUFA and SCD1.

AB - Here, we report the synthesis of polyesters of l-malic acid, β-cyclodextrin, and two other comonomers, resorcinol and salicylic acid that, involved in the polyester chain by direct polycondensation, could improve the antibacterial activity. The copolymers were characterized by thermal analysis, infrared spectroscopy as well as by specific optical rotation values. The thermogravimetric and differential scanning calorimetry (TG–DSC) measurement results showed the influence of the comonomers on the thermal stability of the copolymers, which was higher when ZnO was present in the reaction mixture. The FTIR spectra confirmed the presence of the comonomers in the polyesters and the influence of the ZnO on the products. The specific optical rotation values showed similar tendency, and the results were in accordance with those got by TG–DSC and FTIR techniques. In short, the zinc oxide helped not only in ester formation but improved the polyester stability. Results allowed elaboration of reproducible polyester synthesis with tailor-made characteristic.

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Synthesis method of malic acid di-menthyl ester …

Third, glutamate serves as substrate for the synthesis of N-acetylglutamate, an essential allosteric activator of carbamyl phosphate synthetase I, a key regulatory enzyme in the urea cycle.

Availability of supplements
Amino acids are available either as individual tablets, capsules or pills, in an amino acid complex, or in liquid form.

L-(-)-Malic Acid For Resolution Of Racemates For Synthesis

N2 - Here, we report the synthesis of polyesters of l-malic acid, β-cyclodextrin, and two other comonomers, resorcinol and salicylic acid that, involved in the polyester chain by direct polycondensation, could improve the antibacterial activity. The copolymers were characterized by thermal analysis, infrared spectroscopy as well as by specific optical rotation values. The thermogravimetric and differential scanning calorimetry (TG–DSC) measurement results showed the influence of the comonomers on the thermal stability of the copolymers, which was higher when ZnO was present in the reaction mixture. The FTIR spectra confirmed the presence of the comonomers in the polyesters and the influence of the ZnO on the products. The specific optical rotation values showed similar tendency, and the results were in accordance with those got by TG–DSC and FTIR techniques. In short, the zinc oxide helped not only in ester formation but improved the polyester stability. Results allowed elaboration of reproducible polyester synthesis with tailor-made characteristic.

D-(+)-Malic acid for the resolution of racemates for synthesis

Ma J, Yan R, Zu X, et al: Aldo-ketoreductase family 1 B10 affects fatty acid synthesis by regulatingthe stability of acetyl-CoA carboxylase-alpha in breast cancercells. J Biol Chem. 283:3418–3423. 2008. : :

Tartaric Malic Acids Synthesis: A Source Book of …

Here, we report the synthesis of polyesters of l-malic acid, β-cyclodextrin, and two other comonomers, resorcinol and salicylic acid that, involved in the polyester chain by direct polycondensation, could improve the antibacterial activity. The copolymers were characterized by thermal analysis, infrared spectroscopy as well as by specific optical rotation values. The thermogravimetric and differential scanning calorimetry (TG–DSC) measurement results showed the influence of the comonomers on the thermal stability of the copolymers, which was higher when ZnO was present in the reaction mixture. The FTIR spectra confirmed the presence of the comonomers in the polyesters and the influence of the ZnO on the products. The specific optical rotation values showed similar tendency, and the results were in accordance with those got by TG–DSC and FTIR techniques. In short, the zinc oxide helped not only in ester formation but improved the polyester stability. Results allowed elaboration of reproducible polyester synthesis with tailor-made characteristic.

Malic Acid and Magnesium for Fibro Pain

Zhan Y, Ginanni N, Tota MR, et al: Controlof cell growth and survival by enzymes of the fatty acid synthesispathway in HCT-116 colon cancer cells. Clin Cancer Res.14:5735–5742. 2008. : :

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