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FIG. 3: SYNTHESIS OF BENZIMIDAZOLE DERIVATIVE
Fuloria, "Synthesis, characterization and comparative screening of some newer 2-phaenyl indole and 5-chloro-2-phenyl indole derivatives", Southern Brazilian Journal of Chemistry, vol.
However, there are no reports of the use of ammonium salts as catalysts for the synthesis of benzimidazoles. In continuation, on the synthesis of heterocycles 13, 14 and on the development of synthetic methodologies 15, 17, we herein report a facile method for the synthesis of benzimidazoles by the reaction between amines derivatives and o-phenylenediamine in dimethyl formamide (DMF) as solvent in the presence of iodine as a catalyst, in very good yields.
Imidazole and benzimidazole synthesis - Organic chemistry
Substituted benzimidazole derivatives have found commercial application in veterinarian medicine as anthelmintic agents and in diverse human therapeutic areas such as treatment of ulcers and antihistaminic 5. Similarly, the general synthesis of benzimidazoles is by the condensation reaction of 1, 2-phenylenediamine with carboxaldehydes, carboxylic acids 6, 7, or their derivatives 8, 9 such as, chlorides, nitriles, and orthoesters, under strong acidic conditions, with high temperatures. Benzimidazoles have also been prepared on a solid phase to prove a combinatorial approach 8, 9. The most popular strategies for their synthesis utilize N-alkylation of an unsubstituted benzimidazole 11. Ammonium salts are inexpensive, commercially available reagents for few organic transformation reactions such as halogenation of aromatic compounds and synthesis of 3, 4-dihydropyrimidine-2(1H)-ones 12.
Gupta, "Synthesis and Antimicrobial Profile of Newer Schiff Bases and Thiazolidinone Derivatives", WASET- International Journal of Chemical, Nuclear, Metallurgical and Materials Engineering, Vol.
Benzimidazole synthesis - Organic Chemistry Portal
Fuloria, Synthesis and antimicrobial activity evaluation of some schiff's bases derived from 2-aminothiazole derivatives, Indonesian Journal of Pharmacy, vol.
Synthesis of bioactive molecule fluoro substituted benzothiazole comprising sulphonamide quinazolinyl imidazole for biological and pharmacological screening, Ultra science vol.20(2),281-296 (2008)
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Imidazole and benzimidazole synthesis - Organic …
Synthesisderivative of 9-chloracridine (cyclization) with the next amination, and thenreduction to the ethacridine-base.
Also available following 2-Mercapto Benzimidazole derivatives
Substituted benzimidazole derivativeshave found aplications in diverse therapeutic areas including antiulcers,antihypertensives, antivirals, antifungals, anticancers, and antihistaminics.
Synthesis, 2012, 44, 3049-3054.
Fuloria, Synthesis and antimicrobial profile of newer schiff bases and thiazolidinones derivatives" World Academy of Science Engineering and Technology 2014, 8,12, 1228-1231.
Synthesis of Metal-Organic Frameworks (MOFs): Routes …
From the present study, it can be concluded that the benzimidazole derivatives can potentially be developed into useful anti-anxiety agents, which can prompt future researchers to synthesize a series of benzimidazole derivatives containing a wide variety of substituent’s, with the aim of producing a novel heterocyclic system, with enhanced activity.
General & Introductory Chemistry
Fuloria, Synthesis and antimicrobial activity evaluation of some schiff's bases derived from 2-aminothiazole derivatives, Indonesian Journal of Pharmacy, 2013, 24 (1), 35-39,.
Bachelor of Pharmacy - AIMST University
Synthesis of benzimidazole derivative: The equimolar amount of amines derivatives and o-phenylenediamine were diluted in equimolar amount of dimethyl formamide (DMF) as solvent to a different round bottom flask and both are mixed and stirred for 30 min. and this solution was keeping for overnight and then in this solution we added iodine as catalyst in little amount live this solution for 4 to 5hr at 35-40oC. Finally after 5hr this solution was pour in brine ice solution to avoid emulsified. The mixture was filtered and product was obtained. Because of impurity, washing will be done via sodium bi sulfite & sodium bi carbonate and then recrystalline by absolute ethanol. We obtained pure compound (See fig. 3).
November « 2017 « New Drug Approvals
Fuloria, "Synthesis, characterization and comparative screening of some newer 2-phenyl indole and 5-chloro-2-phenyl indole derivatives", Southern Brazilian Journal of Chemistry, 2012, 20 (20), 69-76,.
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