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Undecanal No N/R See undecyl alcohol.

2.2.2.1 Acetaldehyde A NOEL of 125 mg/kg bw per day was reported for acetaldehyde added to the drinking-water of male and female rats for 4 weeks at level of 0, 25, 125 or 625 mg/kg bw per day (Til et al., 1988); the only treatment-related effect was hyperkeratosis of the forestomach at 625 mg/kg bw per day.

(µg per person per day)   Undecanoic acid No N/R See undecyl alcohol.

Alkylpolyglucoside produced was analysed by FTIR, 1H and 13C NMR spectrometric technique.AB - The purpose of this study is to synthesis alkylpolyglucoside via condensation of decanol with dextrose in the presence of heterogenous catalyst.

Hexyl alcohol USA 4.3 810 14 Europe 13 1900 31 Table 2.

AB - Alkyl β-D-xylobioside and alkyl β-D-xyloside were prepared by the one-pot reaction of xylan and a fatty alcohol, such as 1-octanol, 1-decanol, 2-octanol and 2-ethylhexanol using the cell-free culture filtrate of the xylan-assimilating strain, Aureobasidium pullulans KK415. Using this strain, a novel surfactant, alkyl β-D-xylobioside, was produced as the main product when the alcohol and xylan was incubated at a temperature of 65°C and pH 4.5.

No safety concern USA: 63 Europe: 64 1-Decanol No N/R 1-Decanol is oxidized to its No safety USA: 7 corresponding aldehyde, which is rapidly Europe: 290 oxidized to the acid; metabolism via fatty acid pathways and tricarboxylic acid pathways.

1-Decanol USA 0.037 7.0 0.12 Europe 0.2 28 0.48 26.

No safety concern USA: 61 Europe: 288 Decanoic acid No Yes See 1-decanol; at high concentrations, No safety concern USA: 980 decanoic acid undergoes omega-oxidation.

Europe: 1400 Undecyl alcohol No N/R Undecyl alcohol is oxidized to its No safety concern USA: 11 corresponding aldehyde, which is rapidly Europe: 0.9 oxidized to the acid; metabolism via fatty acid and tricarboxylic acid pathways.

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Decanal USA 0.32 61 1.0 Europe 2.0 290 4.9 27.

N2 - Alkyl β-D-xylobioside and alkyl β-D-xyloside were prepared by the one-pot reaction of xylan and a fatty alcohol, such as 1-octanol, 1-decanol, 2-octanol and 2-ethylhexanol using the cell-free culture filtrate of the xylan-assimilating strain, Aureobasidium pullulans KK415. Using this strain, a novel surfactant, alkyl β-D-xylobioside, was produced as the main product when the alcohol and xylan was incubated at a temperature of 65°C and pH 4.5.

Decanoic acid USA 5.1 980 16 Europe 9.9 1400 24 28.

No safety concern USA: 72 Europe: 160 1-Hexadecanol No Yes 1-Hexadecanol is oxidized to its No safety concern USA: 0.2 corresponding aldehyde, which is rapidly Europe: 3.6 oxidized to the acid; metabolism via fatty acid and tricarboxylic acid pathways.

Undecyl alcohol USA 0.06 11 0.19 Europe 0.006 0.86 0.01 29.

No adverse effects were seen when acetaldehyde in drinking-water at a daily intake level of 0.5 mg/kg bw was given to rats (Amirkanova & Latypova, 1967).

Undecanoic acid USA 0.046 8.7 0.15 Europe 0.032 4.6 0.08 31.

2.2.2.2 Propyl alcohol No adverse effects on the liver were observed when male rats were give 1 or 2 M solutions of propyl alcohol (approximately 60 or 120 mg/kg bw per day) as a drinking-water substitute for 6 or 2 months, respectively.

1-Hexadecanol USA 0.0009 0.17 0.003 Europe 0.025 3.6 0.06 37.

Alkyl β-D-xylobioside and alkyl β-D-xyloside were prepared by the one-pot reaction of xylan and a fatty alcohol, such as 1-octanol, 1-decanol, 2-octanol and 2-ethylhexanol using the cell-free culture filtrate of the xylan-assimilating strain, Aureobasidium pullulans KK415. Using this strain, a novel surfactant, alkyl β-D-xylobioside, was produced as the main product when the alcohol and xylan was incubated at a temperature of 65°C and pH 4.5.

(1961a) Toxicity of heptyl, nonyl and decyl alcohols.

In groups of rats given a 1 M solution of propyl alcohol as their sole source of drinking-water for 4 months, a lower ratio of weight gain to caloric intake compared to controls was observed, but there were no effects on the liver.

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