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Synthesis Design Inc in North Vancouver, BC - …

N2 - Terrestrial biosphere models (TBMs) have become an integral tool for extrapolating local observations and understanding of land-atmosphere carbon exchange to larger regions. The North American Carbon Program (NACP) Multi-scale synthesis and Terrestrial Model Intercomparison Project (MsTMIP) is a formal model intercomparison and evaluation effort focused on improving the diagnosis and attribution of carbon exchange at regional and global scales. MsTMIP builds upon current and past synthesis activities, and has a unique framework designed to isolate, interpret, and inform understanding of how model structural differences impact estimates of carbon uptake and release. Here we provide an overview of the MsTMIP effort and describe how the MsTMIP experimental design enables the assessment and quantification of TBM structural uncertainty. Model structure refers to the types of processes considered (e.g., nutrient cycling, disturbance, lateral transport of carbon), and how these processes are represented (e.g., photosynthetic formulation, temperature sensitivity, respiration) in the models. By prescribing a common experimental protocol with standard spin-up procedures and driver data sets, we isolate any biases and variability in TBM estimates of regional and global carbon budgets resulting from differences in the models themselves (i.e., model structure) and model-specific parameter values. An initial intercomparison of model structural differences is represented using hierarchical cluster diagrams (a.k.a. dendrograms), which highlight similarities and differences in how models account for carbon cycle, vegetation, energy, and nitrogen cycle dynamics. We show that, despite the standardized protocol used to derive initial conditions, models show a high degree of variation for GPP, total living biomass, and total soil carbon, underscoring the influence of differences in model structure and parameterization on model estimates.

T1 - Design, synthesis, and incorporation of fluorous 5-methylcytosines into oligonucleotides

The booming of the shale gas industry is predicted to impact North American's energy landscape. This paper addresses the robust design and synthesis of shale gas processing and natural gas liquids (NGLs) recovery processes under uncertain feedstock compositions. The problem is addressed via three steps. First, we construct an uncertainty set for raw shale gas compositions. Second, we develop a superstructure for shale gas processing and NGLs recovery processes that includes monoethanolamine and diethanol amine absorption processes in an acid gas removal section, triethylene glycol absorption and condensation processes in a dehydration section, standalone and integrated designs of a NGLs recovery process, and a nitrogen rejection process. The proposed superstructure explicitly shows process configurations for the feedstocks in the uncertainty set. In the last step, we propose a two-stage adaptive robust mixed-integer linear programming problem based on the superstructure and a tailored solution method for the proposed model. The obtained robust optimal design is immunized against uncertainty in feedstock compositions.

Synthesis Design Inc at 258 1st St E, North Vancouver, BC V7L 1B3

Redesign & Staging - Evergreen Place, North Vancouver, BC

Terrestrial biosphere models (TBMs) have become an integral tool for extrapolating local observations and understanding of land-atmosphere carbon exchange to larger regions. The North American Carbon Program (NACP) Multi-scale synthesis and Terrestrial Model Intercomparison Project (MsTMIP) is a formal model intercomparison and evaluation effort focused on improving the diagnosis and attribution of carbon exchange at regional and global scales. MsTMIP builds upon current and past synthesis activities, and has a unique framework designed to isolate, interpret, and inform understanding of how model structural differences impact estimates of carbon uptake and release. Here we provide an overview of the MsTMIP effort and describe how the MsTMIP experimental design enables the assessment and quantification of TBM structural uncertainty. Model structure refers to the types of processes considered (e.g., nutrient cycling, disturbance, lateral transport of carbon), and how these processes are represented (e.g., photosynthetic formulation, temperature sensitivity, respiration) in the models. By prescribing a common experimental protocol with standard spin-up procedures and driver data sets, we isolate any biases and variability in TBM estimates of regional and global carbon budgets resulting from differences in the models themselves (i.e., model structure) and model-specific parameter values. An initial intercomparison of model structural differences is represented using hierarchical cluster diagrams (a.k.a. dendrograms), which highlight similarities and differences in how models account for carbon cycle, vegetation, energy, and nitrogen cycle dynamics. We show that, despite the standardized protocol used to derive initial conditions, models show a high degree of variation for GPP, total living biomass, and total soil carbon, underscoring the influence of differences in model structure and parameterization on model estimates.

A palladium-catalyzed Negishi coupling reaction has been developed to synthesize fluorous 5-methyl-cytosines. These fluorous nucleosides are incorporated into the oligonucleotides that correspond to part of the promoter region of Oct4, a master gene that undergoes dynamic DNA demethylation during cellular reprogramming. The separation of the fluorous oligonucleotides from its nonfluorous analogues has been achieved through solid-phase extraction over fluorous silica, suggesting its potential use in probing DNA demethylation (Figure presented).

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Home Designers Listings in North Vancouver, BC | Cylex

N2 - A palladium-catalyzed Negishi coupling reaction has been developed to synthesize fluorous 5-methyl-cytosines. These fluorous nucleosides are incorporated into the oligonucleotides that correspond to part of the promoter region of Oct4, a master gene that undergoes dynamic DNA demethylation during cellular reprogramming. The separation of the fluorous oligonucleotides from its nonfluorous analogues has been achieved through solid-phase extraction over fluorous silica, suggesting its potential use in probing DNA demethylation (Figure presented).

AB - A palladium-catalyzed Negishi coupling reaction has been developed to synthesize fluorous 5-methyl-cytosines. These fluorous nucleosides are incorporated into the oligonucleotides that correspond to part of the promoter region of Oct4, a master gene that undergoes dynamic DNA demethylation during cellular reprogramming. The separation of the fluorous oligonucleotides from its nonfluorous analogues has been achieved through solid-phase extraction over fluorous silica, suggesting its potential use in probing DNA demethylation (Figure presented).

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Bill Curtis & Associates Design Ltd, North Vancouver …

N2 - The booming of the shale gas industry is predicted to impact North American's energy landscape. This paper addresses the robust design and synthesis of shale gas processing and natural gas liquids (NGLs) recovery processes under uncertain feedstock compositions. The problem is addressed via three steps. First, we construct an uncertainty set for raw shale gas compositions. Second, we develop a superstructure for shale gas processing and NGLs recovery processes that includes monoethanolamine and diethanol amine absorption processes in an acid gas removal section, triethylene glycol absorption and condensation processes in a dehydration section, standalone and integrated designs of a NGLs recovery process, and a nitrogen rejection process. The proposed superstructure explicitly shows process configurations for the feedstocks in the uncertainty set. In the last step, we propose a two-stage adaptive robust mixed-integer linear programming problem based on the superstructure and a tailored solution method for the proposed model. The obtained robust optimal design is immunized against uncertainty in feedstock compositions.

Synthesis Design Inc.'s Projects - Houzz

AB - The booming of the shale gas industry is predicted to impact North American's energy landscape. This paper addresses the robust design and synthesis of shale gas processing and natural gas liquids (NGLs) recovery processes under uncertain feedstock compositions. The problem is addressed via three steps. First, we construct an uncertainty set for raw shale gas compositions. Second, we develop a superstructure for shale gas processing and NGLs recovery processes that includes monoethanolamine and diethanol amine absorption processes in an acid gas removal section, triethylene glycol absorption and condensation processes in a dehydration section, standalone and integrated designs of a NGLs recovery process, and a nitrogen rejection process. The proposed superstructure explicitly shows process configurations for the feedstocks in the uncertainty set. In the last step, we propose a two-stage adaptive robust mixed-integer linear programming problem based on the superstructure and a tailored solution method for the proposed model. The obtained robust optimal design is immunized against uncertainty in feedstock compositions.

Interior Design in NORTH VANCOUVER, BC | Hotfrog …

N2 - There is widespread interest in developing fluorescent reporters of protein kinase activity, species that can furnish a visual readout of both when and where intracellular kinases are activated in response to a stimulus. We have constructed and identified, via a combination of rational design, library synthesis, and screening, a difluorofluorescein-appended peptide-based species that responds to protein kinase C phosphorylation in a fluorescently sensitive fashion. The phosphorylation-induced divalent metal ion-mediated 265% enhancement in fluorescence proceeds with a Vmax of 8.5 μmol/min·mg and a Km of 20.5 μM.

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