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The synthetic pathways for the essential amino acids are:

Submarine hydrothermal systems on the early Earth may have been the sites from which life emerged. The potential for Strecker synthesis to produce biomolecules (amino and hydroxy acids) from starting compounds (ketones, aldehydes, HCN and ammonia) in such environments is evaluated quantitatively using thermodynamic data and parameters for the revised Helgeson-Kirkham-Flowers (HKF) equation of state. Although there is an overwhelming thermodynamic drive to form biomolecules by the Strecker synthesis at hydrothermal conditions, the availability and concentration of starting compounds limit the efficiency and productivity of Strecker reactions. Mechanisms for concentrating reactant compounds could help overcome this problem, but other mechanisms for production of biomolecules may have been required to produce the required compounds on the early Earth. Geochemical constraints imposed by hydrothermal systems provide important clues for determining the potential of these and other systems as sites for the emergence of life.

T1 - Sequential Ugi/Strecker reactions via microwave assisted organic synthesis

Waschinski et al. 38 were reported the synthesis of a series of PMOXA and PEOXA polymers, terminated with quarternary ammonium groups. The polymers were prepared via standard cationic ring-opening polymerisation and terminated using a series of N-alkyl-N, N-dimethyl amines as well as pyridine. The materials were investigated regarding their antimicrobial properties by determining the minimal inhibitory concentration against Staphylococcus aureus. The screening showed, that poly (2-methyl-2-oxazoline)-based polymers containing alkyl ammonium functions with alkyl chains of twelve carbon atoms or longer have antimicrobial activity. A pronounced effect of the head group on antibacterial properties was also observed: polymers containing a proton as the headgroup and a dodecyldimethyl ammonium end group were found to be less bactericidal than the analogous polymer with a methyl headgroup. Poly (2-methyl-2-oxazoline) containing a BOC-protected NH2 headgroup, by contrast, showed very high antimicrobial activities, although this effect is not observed in poly (2-ethyl-2-oxazoline)-based polymers.

"Facile multi-decagram synthesis of methyl but-2-ynoate" B.

2 Tertiary Amine/Hydrogen-Bond Donor Catalysis of Asymmetric Strecker Reactions

AB - A convenient four-step asymmetric Strecker synthesis, utilizing (S)-(-)-l-phenylethylamine as the chiral auxiliary reagent, is described for the preparation of (R)-(+)-2-methyl-3-phenylalanine in >98% enantiomeric excess.

You have previously studied the oxidative deamination of glutamate byglutamate dehydrogenase, in which NH3 and ketoglutarateare produced. The -ketoglutarate produced is thenavailable for accepting amino groups in other transamination reactions, but theaccumulation of ammonia as the other product of this reaction is a problembecause, in high concentrations, it is toxic. To keep the level of NH3in a controlled range, a rising level of -ketoglutarateactivates glutamine synthetase, increasing the production of glutamine, whichdonates its amino group in various other reactions.

Ch27 : Strecker Synthesis of amino acids

"Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation" A.

Anti microbialOxazolines is one of the most important structural units of among all heterocyclic compounds. Many organic chemists have synthesized various antimicrobial derivatives which contains oxazolines ring system.V. Padmavathi et al. 36 have prepared Novel sulfone linked bis (heterocycles) 62 having oxazoline moiety in combination with pyrrole from E aroylethenesulfonylacetic acid methyl ester exploiting ester and olefin functionalities. These compounds exhibited greater antimicrobial activity. These compounds were tested for antimicrobial activity at two different concentrations: 100 and 200μg/mL, against Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria) and Escherichia coli, Klebsiella pneumoniae (Gram-negative bacteria) on nutrient agar plates at 37 ºC for 24 h using chloramphenicol as reference drug. The inhibitory activity of those compounds against the Gram-positive bacteria was higher than that of the Gram-negative bacteria.

In this the synthesis and in vitro anti-malarial testing of a series of quinoline–oxazolehybrids had been carried out. These compounds were initially screened on cultures of P. falciparum clone 3D7A and they exhibited anti malarial activity in the 1 µM range.

Regulation of the three pathways also occurs at the two branch points:
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Amino acid synthesis - Wikipedia

AB - Submarine hydrothermal systems on the early Earth may have been the sites from which life emerged. The potential for Strecker synthesis to produce biomolecules (amino and hydroxy acids) from starting compounds (ketones, aldehydes, HCN and ammonia) in such environments is evaluated quantitatively using thermodynamic data and parameters for the revised Helgeson-Kirkham-Flowers (HKF) equation of state. Although there is an overwhelming thermodynamic drive to form biomolecules by the Strecker synthesis at hydrothermal conditions, the availability and concentration of starting compounds limit the efficiency and productivity of Strecker reactions. Mechanisms for concentrating reactant compounds could help overcome this problem, but other mechanisms for production of biomolecules may have been required to produce the required compounds on the early Earth. Geochemical constraints imposed by hydrothermal systems provide important clues for determining the potential of these and other systems as sites for the emergence of life.

Strecker amino acid synthesis | Wiki | Everipedia

So, the synthesis of asparagine is intrinsically tied to that of glutamine,and it turns out that glutamine is the amino group donor in the formation ofnumerous biosynthetic products, as well as being a storage form of NH3. Therefore, one would expect that glutamine synthetase, the enzyme responsiblefor the amidation of glutamate, plays a central role in the regulation ofnitrogen metabolism. We will now look into this control in more detail, beforeproceeding to the biosynthesis of the remaining nonessential amino acids.

How much to know about Gabriel and Strecker synthesis? …

N2 - A convenient four-step asymmetric Strecker synthesis, utilizing (S)-(-)-l-phenylethylamine as the chiral auxiliary reagent, is described for the preparation of (R)-(+)-2-methyl-3-phenylalanine in >98% enantiomeric excess.

How much to know about Gabriel and Strecker synthesis?

An example of present-day use of the Strecker synthesis is amultikilogram scale synthesis of a derivative starting from3-methyl-2-butanone :

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