Call us toll-free

Quick academic help

Don't let the stress of school get you down! Have your essay written by a professional writer before the deadline arrives.

Calculate the price

Pages:

275 Words

$19,50

Our resins for solid phase peptide synthesis vary greatly ..

N2 - We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

Welcome to buy solid phase peptide synthesis resins,merrifield resins, wang resins with our factory

Solid-phase peptide synthesis consists of three distinct sets of operations: 1) chain assembly on a resin; 2) simultaneous or sequential cleavage and deprotection of the resin-bound, fully protected chain; and 3) purification and characterisation of the target peptide. Various chemical strategies exist for the chain assembly and cleavage/deprotection operations, but purification and characterisation methods are more or less invariant to the methods used to generate the crude peptide product.

Resins for Solid Phase Peptide and Organic Synthesis

SPPS (solid-phase peptide synthesis) is a standard method for obtaining peptides

Solvation and swelling of peptide-containing resins in solid-phase peptide synthesis, pp 5463 - 5470, Copyright 1980 American Chemical Society." class="disabled">

AB - We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

Resins for Solid Phase Peptide Synthesis

We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS)

We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

CBL has played a historical role in advancing solid-phase synthesis to the large scale. CBL’s partnership with Roche and the Fuzeon program (a chemically complex anti-HIV peptide) required a manufacturing process capable of producing tons of solid phase resin which was then “loaded” with the necessary Fmoc amino acids. As a result of the CBL’s involvement in the Fuzeon program, the cost of raw materials, particularly resins, has decreased significantly, enabling complex peptides to be produced chemically at the ton scale.

Solid-phase peptide synthesis was invented by Merrifield. This was a revolution in polypeptide synthesis, and is now the accepted method for …
Order now
  • UNMATCHED QUALITY

    As soon as we have completed your work, it will be proofread and given a thorough scan for plagiarism.

  • STRICT PRIVACY

    Our clients' personal information is kept confidential, so rest assured that no one will find out about our cooperation.

  • COMPLETE ORIGINALITY

    We write everything from scratch. You'll be sure to receive a plagiarism-free paper every time you place an order.

  • ON-TIME DELIVERY

    We will complete your paper on time, giving you total peace of mind with every assignment you entrust us with.

  • FREE CORRECTIONS

    Want something changed in your paper? Request as many revisions as you want until you're completely satisfied with the outcome.

  • 24/7 SUPPORT

    We're always here to help you solve any possible issue. Feel free to give us a call or write a message in chat.

Order now

Solid-phase oligonucleotide synthesis - ATDBio

Solid phase organic synthesis is now the core technology employed in the automated routine peptide synthesis as well as in combinatorial chemistry. CBL was founded on the discovery and development of the trityl resins, including , also known as the “Barlos resin”. Today, CBL is recognized as the leading supplier of high-quality resins for solid-phase synthesis.

Peptide Synthesizer, Automated Peptide Synthesizer

Two major chemistries for solid phase peptide synthesis are Fmoc (base labile protecting group) and t-Boc (acid labile a-amino protecting group). Each method involves fundamentally different amino acid side-chain protection and consequent cleavage/deprotection methods, and resins; t-Boc method requires use of stronger HF containing anisole alone or anisole plus other scavengers, where peptide-resins assembled by Fmoc chemistry usually cleaved by less harsh Reagents K or R. Fmoc chemistry is known for peptide synthesis of higher quality and in greater yield than t-Boc chemistry. Impurities in t-Boc-synthesized peptides mostly attributed to cleavage problems, dehydration and t-butylation. For peptide assembly HBTU/HOBt, carbodiimide-mediated coupling and PyBOP/HOBt are the most popular routines. Peptides usually purified by reversed-phase HPLC (high performance liquid chromatography) using columns such as C-18, C-8, and C-4.

ChemPep - Peptide Synthesis, Peptide Array, HATU, …

In 1984 , an American chemist of Rockefeller University won the Nobel Prize for his contribution to the advancement of peptide chemistry. He developed a solid phase peptide synthesis (SPPS) methodology of peptides, which uses a polymer with reactive sites (solid supports, insoluble resin supports) that chemically combine to the developing peptide chain. That solved the problem of previous peptide chemistry. Using Merrifield's technique, the problems associated with low yields due to separation and purification are avoided. The polymer can be filtered and washed without mechanical losses because the polymer is very insoluble.

ChemPep: One stop for peptide synthesis

The most common and commercially available BFC comprise esters (-nitrophenyl, pentafluorophenyl, -hydroxysuccinimide, sulfo--hydroxysuccinimide), isothiocyanates, maleimides, hydrazides, α-haloamides for the reaction with nucleophilic functional groups (-NH2, -SH, -OH) of vector molecules and formation of amide, urea, thiourea, Schiff-base, or thioester bond []. Methods have been developed for the conjugation with peptides by solid-phase peptide synthesis (SPPS) resulting in defined position and number of chelate moieties. The outcome of the conjugation in solution wherein peptides and proteins comprise several reactive sites is very often a mixture of bioconjugate molecules with various content of the chelator. Such heterogeneity may cause the interpretation ambiguity of the performance of such imaging agents. Regioselective conjugation to antibodies was achieved by enzymatic reaction with lysine and glutamine residues using bacterial and human tissue transglutaminase as catalysts [].

Order now
  • You submit your order instructions

  • We assign an appropriate expert

  • The expert takes care of your task

  • We send it to you upon completion

Order now
  • 37 684

    Delivered orders

  • 763

    Professional writers

  • 311

    Writers online

  • 4.8/5

    Average quality score

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order