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275 Words


Synthesis, structure, and reactivity

These include the 7,8-diol-9,10-epoxide for benzo [a]pyrene (Kawabata & White, 1987) and the 3,4-diol-1,2-epoxide for the synthetic compound 7,12-dimethylbenz [a]anthracene (Ladics et al., 1991).

Masuda Y & Kagawa R (1972) A novel synthesis and carcinogenicity of dibenzo [a,l]pyrene.

In experiments in rat liver microsomes in which potential DNA adducts were synthesized and used as standards, four depurination products (one-electron oxidation) and one stable product (diol epoxide pathway) of benzo [a]pyrene were detected (Cavalieri & Rogan, 1985; Cavalieri et al., 1993; Rogan et al., 1993).

Azulene is an organic compound and an isomer of naphthalene

Topical application of the prostaglandin synthetase inhibitor indomethacin after administration of benzo [a]pyrene to mice delayed the onset and reduced the size of the skin tumours.

Marnett LJ, Reed GA, & Dennison DJ (1978) Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives.

Whereas naphthalene is colourless, azulene is dark blue

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