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Posttranslational modification of the protein if required.
PROTEINS are polymers of amino acids joined by peptide bonds (proteins are therefore also known as polypeptides). The number and order of the amino acids contained in a particular protein are prescribed by the DNA sequence of that protein’s gene. The mechanism by which a genetic message is translated from its nucleic acid form to […]
Oppenheim RW, Prevette D, Tytell M and Homma S(1990) Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Developmental Biology 138(1): 104–113.
Components of Protein Synthesis
Steward O and Worley PF (2001) A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proceedings of the National Academy of Sciences of the USA 98(13): 7062–7068.
Napoli I, Mercaldo V, Boyl PP et al. (2008) The fragile X syndrome protein represses activity‐dependent translation through CYFIP1, a new 4E‐BP. Cell 134(6): 1042–1054.
Energy Cost of Protein Synthesis
Messenger RNA (mRNA), the blueprint for protein synthesis, is written in the language of ribonucleotides (A, G, C, U) and is read in blocks of three nucleotides that mean a particular amino acid or termination.
There are four different nitrogen bases, adenine, thymine, cytosine and guanine. The synthesis of a particular protein such as insulin is determined by the sequence in which these bases are repeated (see fig.
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Inhibitors of ProteinSynthesis
Martin KC, Casadio A, Zhu H et al. (1997) Synapse‐specific, long‐term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91(7): 927–938.
Protein Synthesis -Translation and Regulation
Hengst U, Deglincerti A, Kim HJ, Jeon NL and Jaffrey SR. (2009) Axonal elongation triggered by stimulus‐induced local translation of a polarity complex protein. Nature Cell Biology 11(8): 1024–1030.
Drag-and-Drop Protein Synthesis: Transcription - zeroBio
Frey U, Krug M, Reymann KG and Matthies H (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Research 452(1–2): 57–65.
the first step in the protein biosynthesis is the replication.
Sixty three nucleotides are required for synthesising the A chain and ninety for the B chain, plus a codon at the end of each chain,signalling the termination of protein synthesis.
of the first stage of protein synthesis
Castro MG and Morrison E (1997) Post‐translational processing of proopiomelanocortin in the pituitary and in the brain, Critical Reviews in Neurobiology 11(1): 35–57.
Protein Synthesis - what-when-how — In Depth …
Casadio A, Martin KC, Giustetto M et al. (1999) A transient, neuron‐wide form of CREB‐mediated long‐term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99(2): 221–237.
first step in protein synthesis is ..
Osterweil EK, Krueger DD, Reinhold K and Bear MF (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. Journal of Neuroscience 30(46): 15616–15627.
of protein synthesis and protein ..
Following release of the synthesized protein, the ribo-some contains an empty tRNA in the P-site or E-site, and mRNA is still bound with the stop codon in the A-site. This arrangement of components is the post-termination complex. A protein known as the ribosome recycling factor (RRF) promotes the dissociation of this complex in preparation for […]
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