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Prions were first hypothesized in 1982 by Stanley B
However, prions mainly or entirely affect spine and brain tissue, and so the risk of eating whole cuts of meat, like steak, are far less than for hamburger, which is more likely to contain bits of tissue from central nervous system.
The company revenues are composed of disposable product revenues and reusable product revenues. ClearPoint Hardware/Software packages are priced at between $100,000 to $150,000 and ClearPoint disposables are priced at $7,500 per procedure with strong margins.
Prion hypothesis: the end of the controversy?: Trends …
first thought to be a nucleic acid enclosed in a protein coat
explained why traditional methods (UV and ionizing radiation) didn't destroy them
30 years of research could not identify this nucleic acid
Initially thought to be a slow virus because of it's long incubation period
further research found that it differed from traditional virus
UV and ionizing radiation didn't kill it
What does this mean?
prions are smarter than once thought
they sense the diseased ones and adopt a partly effective protective response that reduces the amount of raw material to them from the pipeline for prion production
this protective mechanism is what is causing the long incubation period
What can it be used for?
Westaway and Safar believe by supplementing this natural protective mechanism may be the key to curing the prion diseases
The technology leverages the MRI systems found in most hospitals which reduces the capital outlay and footprint associated with a system that would have its own dedicated visualization technology.
Prion hypothesis: the end of the controversy
If we assume MRIC can grow sales of its functional neurosurgical business at 25% per annum over the next 10 years from 79% currently in this segment, the company would generate about $83 million a year at year 10 which is about a quarter of its annual market opportunity and it’s far from being unrealistic. Keeping current valuation metrics intact at year 10, the company would return slightly less than 10 times on investment. Large medical device companies trade at enterprise value of 4 to 6 times revenues and are growing revenues at much lower levels. If the company grew at its current growth rate, the company would be ten times bigger in just four years.
The figure at right shows a model of two conformations of PrP; on the left is the normal, form, while on the right is the prion form. Note the increased content (green arrows) in the prion version of the molecule. These create an electric and can lead to aggregation.
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Strongest proof yet found for prion hypothesis - The …
The mammalian prion proteins do not resemble the prion proteins of yeast in their amino acid sequence. Nonetheless, the basic structural features (formation of amyloid fibers and a highly specific barrier to transmission between species) are shared between and yeast prions. The prion variant responsible for mad cow disease has the remarkable ability to bypass the barrier to transmission.
Strongest proof yet found for prion hypothesis ..
"This is a timely reminder that prion concerns are not going away and that controls to stop abnormal prions being transmitted to humans through the food system or through blood transfusions must be vigorously maintained."
Fact or Fiction: Infectious Prion Hypotheses | Prions
A typical yeast prion proteins contain a region () with many repeats of the amino acids (Q) and (N); these Q/N-rich domains form the core of the prion's structure. Ordinarily, prion domains are flexible and lack a defined structure. When they convert to the prion state, several molecules of a particular protein come together to form a highly structured fiber (see figure at left). The end of the fiber acts as a template for the addition of free protein molecules, causing the fiber to grow. Small differences in the amino acid sequence of prion-forming regions lead to distinct structural features on the surface of prion fibers. As a result, only free protein molecules that are identical in amino acid sequence to the prion protein can be recruited into the growing fiber. This "specificity" phenomenon may explain why transmission of prion diseases from one species to another (such as from sheep to cows or from cows to humans) is a rare event.
Alzheimer's Disease: Return of the Prion Hypothesis
Because of the early stage, capital requirements and unknown timing of the Stroke and Oncology programs any future contribution to revenues from this expansion of its technology falls in the surprise bucket. The company should provide clearer guidance about those programs in early 2018.
The oligomeric prion hypothesis
"We know there is an antibody that can do this in mice and the Medical Research Council's Prion Unit have managed to engineer a human antibody to do this.
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