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Platensimycin and platencin biosynthesis in …

Ph.D. (2011)

Title of research project:
"Platensimycin and platencin biosynthesis and engineering in Streptomyces Platensis"

Postdoctoral position in Prof. Chris Voigt lab, Department of Biological Engineering, MIT, Cambridge, MA;


Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

199. Rudolf, J. D.; Dong, L.-B.; Huang, T.; Shen, B. (2015) A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Mol. BioSyst. 11:2717-2726. []

Fatty acid biosynthesis is a ..

and platencin biosynthesis.

162. Smanski, M. J.; Peterson, R. M.; Shen, B. (2012) Chapter 8: Platensimycin and platencin biosynthesis in Streptomyces platensis showcasing discovery and characterization of novel diterpene synthases. Methods Enzymol. 515:163-186. []

Platensimycin, platencin, and phomallenic acids, newly discovered natural product inhibitors of the condensation steps in fatty acid biosynthesis, represent new classes of compounds with antibiotic potential.

Proteomic Signature of Fatty Acid Biosynthesis …

Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases.

Expression of the Platencin Biosynthetic Gene Cluster in Heterologous Hosts Yielding New Platencin Congeners
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