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optical tweezers open new opportunity to study the material

BM 517 Novel Applications in Biomedical Optics (3+0+0) 3 ECTS 7
(Biyomedikal Optikte Yeni Uygulamalar)
New research studies on bioimaging, confocal and multiphoton microscopy, optical coherent tomography, spectroscopic diagnostics, tissue engineering with light, laser tweezers and scissors, photodynamic therapy and biostimulation.

was trapped by optical tweezers and put on the surface of a Chinese Hamster Ovary ..

Optical tweezers use the optical forces generated by a laser to capture, or "tweeze", a micron-sized dielectric particle, such as a polystyrene bead.

Optical tweezers thesis Research paper Service

Department of Materials Science and Engineering Graduate student Adam Karcz, advised by Professor Joonil Seog, assembling the optical mini tweezers.

"The optical tweezers will allow us to directly observe, in real time, the process of gene carrier/DNA complex formation and DNA release at the single molecule level," Seog explains.

Microdissection allows one to select and isolate part of a sample and use it for further studies (RT-PCR, protein analysis, selection of live cells). Laser microdissection can also be used with live samples to study recovery after a cut, protein recruitment after photodamage… The system is paired with optical tweezer to manipulate samples.

Sensors | Sections: Physical Sensors | Editorial Board

1. 5 Summary of work presented in this thesis. This PhD thesis is about the statistical and thermodynamic properties of DNA unzipping studied with optical tweezers.

Seog, who previously used optical tweezers to explore the mechanical behavior of cell adhesion molecules, plans to apply the technique to further research in nanomedicine and nanobiotechnology.

The optical tweezers will allow Seog and his team to study the earliest interactions between individual proteins that will lead them to form small complexes called oligomers, and then move on to aggregation.

Optical tweezers thesis
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Faculty - Department of Physics - Sharif

Seog points out that his lab's optical tweezers have two advantages over other most other units: instead of calculating force based on spring constants and displacements, his directly measures force without labor-intensive calibration steps.

Sam's Laser FAQ - Items of Interest

Karcz spent time at the lab with research scientist Steven Smith to learn how to build the tweezers for Seog's Molecular Mechanics Laboratory, as well as create documentation and schematics for it. The Molecular Mechanics Laboratory, directed by Assistant Professor Joonil Seog (joint, Fischell Department of Bioengineering and Department of Materials Science and Engineering), is completing setup of a new optical tweezers unit to be used in studies of protein aggregation, gene delivery and self-assembled biomaterials.

Back to Sam's Laser FAQ Table of Contents

Collagen, the most abundant protein in the body, assembles into an extra-cellular fibrillar gel, which has both viscous and elastic properties. These properties can be determined by using optical tweezers to hold a micron-sized bead within the sample. Measurement of the bead’s thermally induced motion enables the determination of the frequency-dependent viscoelasticity. Rather than only probing response at a single location, holographic optical tweezers create multiple, independent traps, permitting simultaneous tracking of multiple embedded beads and characterization of their correlated motion. By using this technique in a collagen gel, we will be able to determine local and cross-correlated viscoelastic properties, which vary at different locations during its formation. Implications of this research lie in the fields of health and biomaterials. The aim of this work is to devise and validate protocols for using holographic optical tweezers to measure local and through-space viscoelasticity. Rather than using laser deflection to track particle motion, I use a high-speed camera and image analysis to track the simultaneous motion of multiple beads. This approach provides nanometer-scale resolution of particle position at sampling rates up to 2.5 kHz. I compare tracking data collected from the high-speed camera to those collected by the laser deflection method and find a discrepancy in the perceived motion of the bead. I perform many experimental tests to assess the root of this problem. Additionally, I numerically represent bead motion measurements if collected using both methods (laser-deflection method and high-speed camera method) and compare them to the idealized measurement results. In doing so, I learn about the limitations of each method, and how the viscous and elastic properties inferred from the data are affected by each measurement device. Finally, based on my numerical representations, I suggest a simple procedure to gain more accuracy in the viscous and elastic properties for both simple fluids (such as water) and complex fluids (such as collagen solutions) when using each method. This procedure can be used in future holographic optical tweezers-based experiments to obtain an accurate representation of the local and correlated properties of collagen.

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