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Synthesis of C-branched spermine tethered oligo-DNA …

Since that time, there have been many different iterations and advancements in synthesis technology, culminating in a further developmental leap in 2017. A major shortcoming of oligo synthesisers was their wear and the frequency of breakdowns with associated down-time. Here, Eurofins Genomics US turned to an unlikely field for the model – aerospace engineering ̶ completely rethinking the DNA manufacturing process and, once again, succeeding in reshaping the marketplace.

PNA-DNA chimera and are fully compatible with oligo synthesis using ..

Nucleotides are the building blocks of life, and a form of these – oligonucleotides (or oligos) – are short, synthesised DNA strands required by scientists for almost all polymerase chain reaction (PCR)-based research. PCR sees stretches of synthesised DNA (oligo synthesis) amplified by creating a number of identical or near-identical copies and is used in a huge set of basic and applied research applications, across all areas of life science and a whole range of genomic investigations. In most cases, the synthesised oligos are used to determine whether a searched-for DNA sequence is present in a product or biological system.

Synthesise the oligo up to the ..

Oligo Process, Asahi Kasei Technikrom synthesiser), purification, ..

To engineer its next generation DNA synthesiser, Eurofins Genomics US partnered with a commercial-grade, aerospace engineering company. The result was the production of high-quality oligos in a shorter time. Also, owing to the incredible power and speed of the machine, the Eurofins team raised the ceiling on scalability and volume, its innovative design making the production of even extremely small volumes of DNA affordable.

Building a DNA synthesiser to manufacture these oligos is almost like building a small jet engine – both utilise the science of air pressure, air flow, vibration, fluidics, and thermodynamics, inside complex, mechanical engineering. But it was the adoption of aerospace engineering’s reaction to downtime – the sector considers it unthinkable – that facilitated the greatest step-change.

In Vitro using an oligo synthesiser

All oligonucleotides were synthesised on an ABI 394 DNA synthesiser by ..

Scientists who buy oligos demand several conditions: high quality and reliability, rapid turnaround time, low cost, and the right quantity. Unfortunately, previous DNA synthesis technologies failed to accomplish all of these at once. Traditional high-throughput oligonucleotide synthesisers use a lot of reagents and make more DNA than that required in most applications. By contrast, emerging microarray or chip based methods generate too little DNA that, besides requiring additional downstream work before being useful, is only suitable for specific applications, predominantly, gene synthesis.

Direct, solid phase synthesis of an oligonucleotide conjugate of the ..
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