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Biosynthesis Of Silver Nanoparticles Using Murraya ..
By dodging this supply dearth and effectively eliminating quality concerns that can plague cannabis cultivation operations, InMed Pharmaceuticals, with its biosynthesis technology and promising development pipeline, has established itself as a company to watch as Big Pharma begins to set its sights on the future of pain relief and the increasing value of biotechs to the cannabis industry.
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Hypoxia is regarded as a key feature of the tumor microenvironment that significantly influences tumor treatment response. An albumin-stabilized gold nanoparticle was synthesized for tumor hypoxia imaging (Figure a) . The nanoparticle was modified with hypoxia-sensitive nitroimidazole moiety, which was converted into amine groups in the presence of nitroreductase. Conversion from the nitro group of nitroimidazole to the amino group helped increase the zeta potential of the prepared nanoparticle, which thereby improved cell internalization for accumulation at the tumor . The designed nanoparticle displayed enhanced X-CT imaging for tumor hypoxia
Nanoparticle Applications - Bio-Synthesis Inc
18. Elzoghby AO, Samy WM, Elgindy NA. Albumin-based nanoparticles as potential controlled release drug delivery systems. 2012;157:168-82
a) Schematic of the effects of albumin corona on the nanoparticles Various plasma proteins are adsorbed onto the nanoparticles after they are injected into the blood; the albumin corona around the nanoparticle inhibits the adsorption of plasma proteins. b) The scheme of albumin-stabilized magnetic nanoparticle and its multifunctional applications in biomedicine. Figure (b) adapted with permission from .
Green biosynthesis of silver nanoparticles using …
Robust, high-yield and cost-effective biosynthesis technology like this could eventually acquire substantial market share that is currently held by some of today’s leading medical marijuana producers, such as Aurora Cannabis, Inc.
Albumin-stabilized cationic gelatin (C-gel) nanoparticle could be loaded with DOX/DNA intercalation complex . The prepared nanoparticle was responsive to pH and tumor-specific matrix metalloproteinases (MMPs). When the C-gel was digested by the MMPs, the loaded DOX/DNA intercalation was released and further digested by deoxyribonucleases to release DOX completely. experiments demonstrated that the designed drug delivery system with significantly low cardiotoxicity was more powerful than free DOX in terms of cancer treatment.
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Mycogenic silver nanoparticle biosynthesis and ..
On the basis of the high biocompatibility and long blood circulation half-life of albumin, many studies have been devoted to the development of albumin-stabilized nanoparticles for biomedical applications [-]. Albumin could be introduced during nanoparticle synthesis or stabilizer replacement [-].
Silver Nanoparticles Synthesis And Applications …
38. Zhang C, Fu YY, Zhang X. . BSA-directed synthesis of CuS nanoparticles as a biocompatible photothermal agent for tumor ablation . 2015;44:13112-8
International Journal of Food Microbiology - …
Cisplatin cannot effectively bind to albumin by non-covalent interaction. Therefore, a series of cisplatin prodrugs with axial ligands was designed to mimic the binding ability of fatty acids . Cisplatin could be released from prodrugs by intracellular reduction with the loss of axial ligands. Aliphatic tails with different lengths exhibited varied cellular uptakes and cytotoxicities. The cisplatin prodrug with hexadecyl chain was the most potent among the synthesized prodrugs. Computation showed that prodrug was buried inside albumin, which helped preserve its stability in the human blood. To improve the tumor-targeted drug delivery, a fatty acid-modified drug was loaded into the albumin and HER2-binding affibody fusion proteins . experiments demonstrated a specific cell uptake by the HER2 positive cells, which indicated a potential ability to perform tumor-targeted drug delivery.
Strategies for Preparing Albumin-based Nanoparticles …
For example, bacteria or yeast-based systems are currently employed to make pharmaceuticals like biosynthesized insulin used daily by millions of diabetics worldwide.
InMed Pharmaceuticals, Inc. (OTCQB: IMLFF)| Breaking …
FT-IR spectra confirmed, biomolecules exist on surface of the nanoparticles. In fact, the interactions of biomolecules to nanoparticles affect size and modify the surface of nanoparticles to enhance solubility, biocompatibility, and toxicity reduction. Remarkable stability of biosynthetic Ag-NPs and low toxicity of these nanoparticles may be dependent on the nature of protective layer on surface of biosynthetic nanoparticles.
Journal of Nanoscience and Nanotechnology
The sophistication of InMed’s biosynthesis platform for drug engineering is evident from examples like the ocular hydrogel formulation being developed in conjunction with the University of British Columbia.
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