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Multiregional hypothesis - ScienceDaily
This Funding Opportunity Announcement (FOA) supports applications to develop and implement a Clinical Coordinating Center for investigator-initiated multi-site clinical trials (Phase II and beyond). Trials for which this FOA applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see ). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website: .
Are appropriate facilities and resources available to adequately coordinate a multi-site clinical trial? Is there strong evidence that the institutions have the available resources needed to conduct a multi-site trial at the CCC and the performance sites?
The "Multiregional" Hypothesis - OoCities
This FOA supports applications to develop and implement a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials (Phase II and beyond). Multi-site clinical trials are defined as trials that enroll from two or more recruitment sites. Trials for which this FOA applies are expected to contribute to the evidence base for important health matters of relevance to the research mission of NHLBI and meet the NIH definition of a clinical trial (see ). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website: . In addition to scientific relevance and excellence, these clinical trials are expected to be conducted with a high degree of efficiency, with streamlined administrative procedures wherever possible.
Astonishingly, critics of ethnic federalism/ multi-national federalism usually fail to note that the major federal failures, including the Soviet Union, Czechoslovakia, Yugoslavia and Nigeria, were, in practice, sham or pseudo-federations. In several cases, they were forced together. They were often, in practice, tightly centralized states. They lacked democracy. This last fact alone meant that their governments were unrepresentative of their populations, and that there was no possibility of dialogue or cooperation among their different national communities. It is hardly surprising that their minorities broke free when the opportunity arose. All of the communist and post-colonial federations that broke apart were economically weak. Because of corruption or the shortcomings of central planning, they could not provide a responsible or growing standard of living for their populations. Relatively enterprising regions of these states, such as Slovenia or the Baltic republics, found this particularly difficult to deal with.
Multi-Regional Hypothesis Flashcards | Quizlet
The chronology in the Middle East does not support the Multiregional Model where Neanderthals and anatomically modern humans overlapped for a long period of time.
Proponents of the Multiregional Model, such as Milford Wolpoff, cite evidence in Asia of regional continuity. They see an evolutionary link between ancient Homo erectus in Java right through to Australian aborigines. A possible problem with this view is that recent dating of late surviving Homo erectus in Indonesia suggests that they survived here until 50,000 years ago, which is potentially when fully modern humans may have arrived in the region from Africa.
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HUMAN EVOLUTION / MULTIREGIONAL HYPOTHESIS - …
The multiregional view posits that genes from all human populations of the Old World flowed between different regions and by mixing together, contributed to what we see today as fully modern humans. The replacement hypothesis suggests that the genes in fully modern humans all came out of Africa. As these peoples migrated they replaced all other human populations with little or no interbreeding.
New DNA Evidence Supports Multiregional Evolutionary Model?
China may contain the best evidence for supporting the Multiregional Model. Here there are discoveries of a couple of skulls dated to roughly 100,000 years ago that seem to possess a mixture of classic Homo erectus and Homo sapiens traits. Better geological dating and more complete specimens are needed to more fully assess this possibility.
DNA Evidence Supports Multiregional Evolutionary Model
Facilities and Other Resources: Describe the facilities and resources available for the coordination of a multi-site clinical trial, including project management software that will be used. Describe how the infrastructure at the CCC and performance sites will facilitate the efficient operation of the proposed multi-site clinical trial.
has further discredited the multiregional hypothesis.
The Multiregional Continuity Model15 contends that after Homo erectus left Africa and dispersed into other portions of the Old World, regional populations slowly evolved into modern humans. This model contains the following components:
Multiregional origin of modern humans - Wikipedia
The PD(s)/PI(s) of the clinical trial must be experienced in the conduct of multi-center clinical trial coordination and management, including success in meeting milestones and timelines, and have expertise in the content area of the proposed clinical trial. The experience of each PD/PI and all Key Personnel must be carefully documented and roles and responsibilities must be well defined. In addition, the responsibilities and authority of each PD/PI must be specified. The application must ensure that a multidisciplinary team of appropriate personnel (clinician, statistician, data manager, study coordinator(s), etc.) are proposed at the contributing institutions to facilitate the implementation of all aspects of the clinical trial, including recruitment of subjects, design/implementation of the clinical protocol, and coordination of roles/responsibilities of the CCC leadership.
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