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ENVIRONMENTAL HEALTH CRITERIA FOR METHYL ETHYL KETONE

Interaction of MEK with other solvents and their metabolitesa Route of administration, Dose and/or Exposure Effects/results Reference species (strain), concentration number and sex n-Hexane Inhalation, rat, 820 mg/m3 (200 ppm) MBK; 8 h/day, muscular weakness lasted longer after exposure to Duckett et al.

Abdel-Rahman MS, Hetland LB, & Couri D (1976) Toxicity and metabolism of methyl n-butyl ketone.

Methodology for analysing air samples recommended by the United States Environmental Protection Agency (US EPA) can detect MEK and most other mono-functional aldehydes and ketones at the 3-6 µg/m3 (1-2 ppb) level (Riggin, 1984).

IRPTC (1987) Methyl ethyl ketone.

The preparation of DNPH derivatives also forms the basis for a simplified, non-specific method for roughly measuring high levels of ketones and aldehydes without the use of sophisticated laboratory equipment (Smith & Wood, 1972).

MEK is also used for degreasing metals, in the manufacture of magnetic tapes, inks and smokeless powder, and as a chemical intermediate in the production of methyl ethyl ketoxime, MEK peroxide, methyl isopropyl ketone and many other compounds.

Health effects of methyl ethyl ketone.

The US Environmental Protection Agency estimated that 1909 tonnes of MEK was emitted in motor vehicle exhaust in the USA in 1987 ("Mobile source estimates for methyl ethyl ketone"; personal communication by J.H.

This gives a percutaneous absorption of 5-10 µgÊcm-2Êmin-1, which is identical to the value measured for methyl isobutyl ketone by DiVincenzo et al.

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Absorption of methyl ethyl ketone.

7.3.1 Behavioural testing Neurotoxicity studies have been carried out on MEK, usually as part of studies on the neurotoxicity of methyl isobutyl ketone (MIBK) and MIBK/MEK mixtures.

US EPA (1986) Health effects assessment for methyl ethyl ketone.

from CO2 laser; automated, computer- vapours simultaneously and continuously (1984) controlled system Trapping in DNPH; colour matching 300 mg/m3 working range is 300-1200 mg/m3; other Smith & Wood against standards aldehydes and ketones interfere; method (1972) requires no specialized equipment Water Separation from water sample by heated 0.05-1.0 water samples must be preserved from bacterial Pellizzari et al.

Methyl ethyl ketone (EHC 143, 1992) - INCHEM

Effects of methyl ethyl ketone on microorganisms Organism Species, strain Concentration Effect Reference (mg/litre) Prokaryotes Cyanobacterium (Blue-green alga Microcystis aeruginosa 120 inhibition of cell multiplication Bringmann & Kuhn (1978) Bacteria Pseudomonas putida 1150 inhibition of cell multiplication Bringmann & Kuhn (1977a) Photobacterium phosphoreum 5050 50% reduction in light output Curtis et al.

beta-naphthyl methyl ketone, 93-08-3 - The Good …

Effects of methyl ethyl ketone on aquatic organisms Species Concentration Effects and comments pH Temperature Hardness Reference (mg/litre) (°C) Crustacea Artemia salina 1950 24-h LC50, bottles not not given not given not given Price et al.

Methyl ethyl ketone (EHC 143, 1992) - IPCS INCHEM

In every study in which the dose of n-hexane, methyl butyl ketone (MBK), or 2,5-hexanedione (2,5-HD) was large enough and sustained for a sufficient period, clinical signs of neural degeneration were produced.

Ethyl methyl ketone CAS 78-93-3 | 109708

The property of potentiation of hexacarbon neurotoxicity is not unique to MEK, but is shared at least by methyl n-propyl ketone, methyl n-amyl ketone and methyl n-hexyl ketone, none of which appear intrinsically neurotoxic (Misumi & Nagano, 1985).

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