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Method For The Synthesis Of Curcumin Analogues - …

T1 - Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues

Synthesis of New Curcumin Analogues from Kulit …

N2 - An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K 2CO 3 in toluene-EtOH-H 2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.

Synthesis and Biological Evaluation of Curcumin Analogues

Advanced Textile Materials: Synthesis of some Curcumin Analogues under Ultrasound Irradiation

Similar observations were reported for conifers.
Pharmaceutic industries have developed stilbene derivatives which have estrogenic activity (non-steroidal estrogens) such as diethyl stilbestrol.

Diarylheptanoids belong to a compound group having phenyl rings at 1,7 positions of n-heptane, such as curcumin and several similar analogues found in the rhizomes of the ginger () family ().

AB - An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K 2CO 3 in toluene-EtOH-H 2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.

General method for the synthesis of 3,5-bis ..

Current research covers aspects of clean technology which are directed towards the major challenges facing humanity in the 21st Century - in being able to gain accessto complex functional molecules and materials for tackling energy, health andenvironmental issues. This includes: (i) The use of patented thin film microfluidicsin controlling chemical reactivity and selectivity in organic and inorganic synthesis,controlling self assemble processes from small molecules to viruses,controlling kinetic versus thermodynamic metal organic frameworks (MOFs), controlling'top down' and 'bottom up' synthesis of nano-materials, and fabricating singlecell algal-graphene hybrid material for waste water treatment. (ii) Solar celltechnology based on the frustules of single cell diatoms. (iii) Utilisation ofbiomass in developing processes and products without generating waste. (iv)Applications of the compounds and materials in (i) - (iii), for example indevice technology, drug delivery and drug development, and waste watertreatment.

An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K 2CO 3 in toluene-EtOH-H 2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.

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