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local estrogen biosynthesis in males ..

The localbiosynthesis of estrogens in breast cancer depends on paracrineinteractions between malignant epithelial cells and proximalfibroblasts and vascular endothelial cells.

Local estrogen biosynthesis in males and females.

Estradiol and estrone were markedly and statistically significantly more toxic in the presence of metabolic activation (from livers of pregnant and non-pregant females and Aroclor 1254-treated adult male rats), but metabolic activation attenuated the embryotoxic effects of ethinylestradiol, tamoxifen, and erythrohexestrol and had no effect on other estrogens.

The role of local estrogen biosynthesis in males …

(1974) Unconjugated estrone, estradiol and FSH and LH in prepubertal and pubertal males and females.

Sperm morphology and in the percentage of the oestrous cycle spent in 10 females) vaginal cytology evaluated oestrus but this effect did not achieve statistical significance (P > 0.05) Mice Males and females given 0, 0.5, 1, Developmental malformations (including NOEL: 53 mg Lecyk (C57BL and 1.5, 2, 3 or 4 g copper sulfate/kg hydrocephalus, encephalocoeles, and abnormalities of Cu/kg body (1980) DBA, groups feed (approximately 0, 27, 53, 80, the ribs and vertebrae) occurred in groups of both weight per of 7-22 106, 159 or 213 mg Cu/kg body strains given > 3 g/kg feed.

The intratumoral metabolism and synthesis of estrogens, as a result of the interactions of various enzymes, is more important than blood uptake to maintain mammary gland estrogen levels in menopausal females.

The role of local estrogen biosynthesis in males and females.

LO, Jones, M et al, The role of local estrogen biosynthesis in males and females.

(as observed in males and in early pubertal females) estrogen may ..
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