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H., His6 tag-assisted chemical protein synthesis.

The reaction wascarried out under solvent-free conditions in most cases. failed to yield any .Project # 3 Work in progressUtility of III) tosylate and iron(III) triflate in addition of indolesto chalconesThe conjugate addition of indoles to chalcones cangenerate a variety of useful substituted indoles with biological activities.

M., Synthesis of bio-inspired hybrid polymers using peptide synthesis and protein engineering.

R.; Lober, S.; Hubner, H.; Gmeiner, P., Click chemistry on solid phase: parallel synthesis of -benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands.

Iron(II) Trifluoromethanesulfonate | AMERICAN …

W., Protein semi-synthesis: New proteins for functional and structural studies.

R., Activity-Based Protein Profiling Reagents for Protein Arginine Deaminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe.

B., Synthesis of azide-alkyne fragments for click' chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols.

Copper(II) Trifluoromethanesulfonate 34946-82-2 | TCI …

R.; Waldmann, H., From protein domains to drug candidates: Natural products as guiding principles in the design and synthesis of compound libraries.

Hence we attempted the reaction with a range of acetals and foundpromising results. To the best ofour knowledge this is the first example of the use of acetals in the reaction (Scheme 2). Since acetals are frequently used toprotect aldehydes, this method allows the direct synthesis of usefulheterocycles from acetals without the need for an additional deprotection step.

A common method fortheir synthesis is the reaction, which is aone-pot condensation of an aryl aldehyde, urea (or thiourea), and ethylacetoacetate. . However, many of these catalysts such as BF3∙Et2Oand AlCl3 are corrosive and/or toxic. Our continued interest inenvironmentally friendly organic synthesis prompted us to investigate theutility of III) tosylate as a catalyst for the reaction (Scheme 1). Scheme 1Theuse of acetals in the reaction is alsoreported. III)tosylate is an attractive catalyst for the reaction because of its low cost, low toxicity, and ease of handling. Theobservation that a solution of Althoughthe reaction worked with lower catalyst loading, the best results were obtainedwith the use of 5% catalyst. Both isopropanol and octane worked assolvents. Although octane is lessenvironmentally friendly than isopropanol, it was easily recovered using arotary evaporator or by decantation and recycled. Both procedures avoid an aqueous work-upand hence large aqueous waste streams were avoided, thus adding to the greenaspect of the methodology. We havepreviously shown that III) tosylate is anefficient catalyst for the deprotection of acetals.

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