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Introduction to Gold Nanoparticle Characterization
Wu et al. reported polysaccharide-based hybrid nanogels that combine functional building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release within a single nanoparticle system for combined diagnosis and therapy. The hybrid nanogels were synthesized by in-situ immobilization of CdSe QDs in the interior of the dual responsive (pH and temperature) hydroxypropylcellulose -poly (acrylic acid) (HPC-PAA) semi-interpenetrating polymer networks. The HPC-PAA-CdSe hybrid nanogels combine a strong trap emission at 741 nm for sensing physicochemical environment in a pH dependent manner and a visible excitonic emission at 592 nm for mouse melanoma B16F10 cell imaging. The hybrid nanogels also provide excellent stability as a drug carrier. They not only provide a high drug loading capacity for a model anticancer drug, temozolomide, but also offer a pH-triggered sustained-release of the drug molecules in the gel network.
Yeast in Nanoparticle Synthesis: Kowshik et al., have demonstrated that MKY3, a silver-tolerant yeast species, when challenged with soluble silver in the log phase of growth, majority of silver precipitate extracellularly as elemental nanoparticles. When challenged with soluble silver in the log phase of growth, based on differential thawing of the sample, for separation of the Metallic nanoparticles from the medium 29.
Tohoku Univ., IMRAM, Hybrid Nanoparticle Lab., Introduction
23. Hayashi K, Moriya M, Sakamoto W, Yogo T. Chemoselective synthesis of folic acid-functionalized magnetite nanoparticles via click chemistry for magnetic hyperthermia. 2009;21:1318-25
17. Laurent S, Dutz S, Häfeli UO, Mahmoudi M. Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. 2011;166:8-23
Introduction to metal-nanoparticle plasmonics
MRI is a diagnostic imaging modality and provides anatomical information.[-] Superparamagnetic iron oxide nanoparticles (SPIONs) are used as negative contrast agents for MRI, but their application is limited mainly to the detection of liver cancer. Therefore, MRI contrast agents for the detection of non-liver cancer have been studied. In the development of MRI contrast agents, ensuring safety is the primary issue. In this regard, SPION-based materials are promising as MRI contrast agents because SPIONs are already used in clinical practice and are believed to be non-toxic.
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Introduction: Nanoparticle Chemistry - Chemical …
Viruses in Nanoparticle Synthesis: Biological synthesis of nanoparticles has been extended to biological particles like viruses, proteins, peptides and enzymes. Cowpea chlorotic mottle virus and cowpea mosaic virus have been used for the mineralization of inorganic materials 35. Tobacco mosaic virus has shown to direct successfully the mineralization of sulphide and crystalline nanowires. One step further, peptides capable of nucleating Nano crystal growth have been identified from combinatorial screens and displayed on the surface of M13 bacteriophage 36.
Green Synthesis of Metallic Nanoparticles via ..
The importance of developing environment-friendly sustainable metal nanoparticle producing technologies using the principles of green chemistry is discussed. The first part of this review briefly surveys the use of microorganisms and the second, more extensive part, examines the role of plants in synthesizing metal nanoparticles.
Nanocomposites: synthesis, structure, properties and …
Actinomycetes in Nanoparticles Synthesis: The monodispersity of the silver and gold nanoparticles produced either intracellular or extracellularly is of interest to scientists. But it was not very high and was far inferior to that obtained by conventional methods. Most of the actnimycetes especially the thermophilic actinimycetes, Thermomonospora sp was exposed to gold and silver irons and the metals got reduced extracellularly 33. These micro-organisms have developed numerous special adaptations to survive in such extreme habitats which include new mechanism of enzyme transduction, regulating metabolism, maintaining the structure and function of the membrane. Actinomycetes are micro organisms that can share important characteristics of fungi and bacteria 34. Even though the Actinomycetes have close relation with the mycobacterium and coryneforms, they were originally designated with ‘ray fungi’ (Strahlenpilze). These actinomycetes are able to produced secondary metabolites. The nanoparticles were also found to be non-toxic to the cells which continued to multiply even after the formation of the nanoparticles.
Nanoparticles Applications and Uses - …
Silver Toxicity: The toxicity from the silver is observed in the form of argyria when there is a large open wound and large amount of silver ions are used for dressing. There are no regular reports of silver allergy40. Important to note despite and decades of use the evidence of toxicity of silver is not still clear. Wide applications of nanotechnology are possible in the fields like electronics, engineering, medicine, etc., but the possible side effects of nanoparticles have not been much studied. Hence, detailed study needs to carry out before the introduction of products related to nano medicine in the market 41.
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