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Quantitation of intrathecal immunoglobulin synthesis …
Eosinophilic meningoencephalitis due to the nematode Angiostrongylus cantonensis, which is endemic to Cuba, occurs in children and is due to accidental contact with soil snails. The course is less often fatal than in adult patients in southeastern Asia. Cerebrospinal fluid (CSF) and serum samples from 24 pediatric patients were analyzed and evaluated in CSF/serum quotient diagrams (Reiber graphs) to characterize the neuroimmunological response and the blood-CSF barrier dysfunction that occur in the course of the disease. At the time of the first diagnostic lumbar puncture, together with eosinophilic pleocytosis (1,920 6 400 cells/ml), intermediate blood-CSF barrier dysfunction (i.e., an increased CSF/serum albumin quotient) with no intrathecal immunoglobulin G (IgG), IgA, and IgM class response was observed in all cases. Seven days later, at the time of early clinical recovery, the blood-CSF barrier dysfunction was normalized in 75 % of the patients, but meanwhile, intrathecal immunoglobulin synthesis emerged in all cases, as either a two-class response (IgG and IgA in 85 % of the patients) or a three-class response (IgG, IgA, and IgM; 30%). The fraction of eosinophilic cells (40%) remained large despite a decreasing total cell count. The neuroimmunological pattern of this inflammatory response to the parasite and its toxins is discussed with regard to the CSF patterns of other infectious diseases caused by bacteria or viruses. Eosinophilic meningitis or meningoencephalitis induced by
Here, we discuss that the different between intrathecal synthesis patterns of major immunoglobulins found in patients from different geographical regions not directed linked is due to different circulating strains that produce typical patterns.">
Intrathecal synthesis of free immunoglobulin light …
Here, we discuss that the different between intrathecal synthesis patterns of major immunoglobulins found in patients from different geographical regions not directed linked is due to different circulating strains that produce typical patterns.
In an individual B cell, only one of the chromosomes undergoes complete V-D-J recombination leading to expression of heavy and light chains. A mechanism exists that prevents the other chromosome from being rearranged and therefore expressed in the same cell. This is called allelic exclusion. It prevents a B cell from expressing two entirely different immu-noglobulins or BCRs. A similar mechanism operates during synthesis of TCRs in T cells [see T Cell Receptors, below].
Evidence of intrathecal immunoglobulin synthesis in …
We detected intrathecal IgG and IgA synthesis at AD patients, while the synthesis of all the three immunoglobulins was characteristic for the Jakob-Creutzfeld disease.
We specified the concentration of liquor immunoglobulins with the nephelometrical method, and concluded the presence of intrathecal immunoglobulin (IgG, IgM and IgA) synthesis on the basis of the Link index.
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Immunoglobulins intrathecal synthesis evaluation in …
The most intriguing aspect of the genetic control of im-munoglobulin synthesis is the diversity of the product: plasma cells can make antibodies that react with an indefinite number of different antigenic sites. How can DNA code for such a large number of antigens, many of which have only recently (on the evolutionary time scale) come into existence?
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