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prevents proliferation and collagen synthesis by fibroblasts ..

A major fraction of total daily energy demand arises from restingmetabolism, and it is thus important to note that resting metabolismdecreases with aging, by about 10% from early adulthood to the age ofretirement, and a further 10% subsequently. One reason is theloss of metabolically active muscle mass and parallel increase inmetabolically inert depot fat. In later old age, there may alsobe some overall reduction in cellular metabolism. Food intakemust be correspondingly adjusted if body fat is not to increasefurther. A low total intake of food may fail to satisfy dailyrequirements of protein and other key nutrients, particularlycalcium. One important by-product of a physical activityprogram for the older senior is thus an increased intake of keynutrients without recourse to the provision of synthetic dietarysupplements.

no other evidence of alteration from normal in collagen synthesis ..

Thyroid hormone contains tyrosine, and we should also be taking tyrosine supplementally. It’s a great supplement for cognitive function and dopamine synthesis. I think there are a lot of benefits to be gained from learning about individual l amino acids taken in a pure pharmaceutical grade form that you mix in water or that you take on a completely empty stomach – maybe with a proteolytic enzyme to help it digest.

Thyroxine is important for collagen synthesis

Credit must be given to Sharon Meglathery, MD for elucidating the pathophysiology and various related theories of EDS. Credit also goes to Deborah Cusack for elucidating what is now referred to as "The Cusack protocol" and the use of polysaccharides as a viable treatment.

Homocysteine is a compound relative to the naturally occurring amino acid cysteine that causes damage to collagen, elastin, and proteoglycans. Deficiencies in folic acid and vitamin B 12 correspond to elevated levels of homocysteine, while supplementation with these nutrients can bring levels back to normal. Since homocysteine is usually found bonded to other proteins, it is considered to have a harmful effect upon protein function. Homocysteine is also implicated in shortening telomeres.

Copper is an important cofactor in collagen synthesis; LOX ..

Muscle strength can be greatly improved by as little as 8 weeks ofresisted training, even in 90 year old subjects (3). Proteinsynthesis proceeds more slowly than in a younger adult, butcross-sectional comparisons between active and inactive individualssuggest that much of the wasting of lean tissue can be avoided byregular resisted exercise. Stronger muscles further enhancefunction by stabilizing osteo-arthritic joints, reducing the risk offalls, and lessening the extent of dyspnea.

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