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Interesting discussion. As I understood it you had to have enough magnesium to enable d3 to synthesise and adequately control calcium absorption. Hence, if you have enough magnesium and get 20 minutes of strong sunlight per day on exposed skin and eat a relatively balanced diet, then you do not need calcium supplements. There have indeed been numerous cases reported in the US of hypercalcaemia in older women who are put on high doses of calcium. These are reflective of the problems associated with Sippy Syndrome back in the mid 20thC when men suffered the same problem after taking the Sippy regime for acid indigestion.
The irregular issue with vit d deficiency is that many people in sunnier climates suffer from it. They shouldn’t. Therefore is the issue with low magnesium rates which, apparently, many people suffer from. Magnesium used to be obtained through natural high content in water, these days the tendancy is to make water softer.
I was never aware that it was magnesium that controlled calcium directly – the intermediary is Vit d3.
I too would be interested to know about the study that Dr Briffa refers to. How many participants, what were other levels, were any symptoms reported, who paid for it, who did it, which calcium levels were monitored and, more importantly, when – calcium fluctuates very quickly and if levels aren’t measured at the right time they can have reverted to normal.
Depending on how low they are to start with, I will typically dose them at 1000IU per every 15kg/20kg of body weight. I started myself on 5000IU and pushed my serum Vit D to just slightly over 200nmol/L. At this point I pulled the doseage back to 4000IU over winter and slightly less over the summer months here in New Zealand. My most recent test, at the end of a NZ summer, showed my levels to be 133nmol/L. By the time daylight savings ends (in a couple of weeks time), our sun will be sufficiently low in the sky that any meaningful vitamin D synthesis will cease to occur (I use the rule of thumb that if your shadow is taller than you, there will be insufficient UVB-R striking the ground for vitamin D synthesis in your skin to occur). At this point I’ll restart daily dosing at 1000IU/20kg (4000IU per day for me).
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The approach adopted was initially to synthesise a known MIP using diazepam as template then to prepare novel MIPs using other benzodiazepines and analogues of QA compounds as templates.
In the first of these stages, an anti-diazepam MIP was synthesized using methacrylate acid (MAA) as the monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-liner and was then ground and prepared for use as an SPE sorbent by packing it into SPE cartridges.
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The results from MISPE protocol showed better selectivity, specificity and accuracy toward diazepam (template molecule) and other benzodiazepines that display a similar resemblance to diazepam in terms of molecular structure.
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