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KW - C-nucleosides: thiazofurin analogues

The multistep continuous flow synthesis of indolylthiazoles 1a1l is presented in . For all entries (1–12), a DMF solution of phenylhydrazine hydrochloride (10a) was pumped into the second chip in order to study the reaction scope of α-bromoketones 5. The overall yields for the three-step, two-chip sequence were high (43%–65%) when using aromatic α-bromoketones 5, averaging at least 70% yield for each chemical transformation. Acetophenone substrates bearing either electron-donating (entries 2, 3 and 4), electron-withdrawing (entries 10 and 11), or halogen substitution (entries 7, 8 and 9) as well as 2-naphthyl (entry 6) and heteroaromatic (entry 12) were found to be suitable for this process. Importantly, these data largely represent the current supply of commercially available α-bromoketones, yielding complex drug-like compounds for extensive biological evaluation and/or continued chemistry.

T1 - Synthesis of new 1,4-dihydropyridine derivatives containing thiazolyl substituents
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N2 - A series of 4-[2-methyl (or aryl) thiazole-4-yl]-2,6-dimethyl-3,5-diacetyl (or dibenzoyl) 1,4-dihydropyridines were synthesized using a modified Hantzsch reaction involving the condensation of the corresponding aldehyde with acetyl acetone or benzoyl acetone. The preparation of the corresponding aldehydes (2-methylthiazole-4-carboxaldehyde and some 2-arylthiazole-4-carboxaldehydes) was achieved by a simplified protocol of the published synthesis.

Various laboratory methods exist for the of thiazoles.

T1 - Thiazole C-nucleosides. III. Synthesis of pyranose analogues of tiazofurin
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Thiazoles are characterized by larger pi-electron than the corresponding and have thereforegreater .This is evidenced by the position of the ring protons in (between 7.27and 8.77 ppm), clearly indicating a strong .

The multistep continuous flow assembly of 2-(1H-indol-3-yl)thiazoles using a Syrris AFRICA® synthesis station is reported. Sequential Hantzsch thiazole synthesis, deketalization and Fischer indole synthesis provides rapid and efficient access to highly functionalized, pharmacologically significant 2-(1H-indol-3-yl)thiazoles. These complex, drug-like small molecules are generated in reaction times of less than 15 min and in high yields (38%–82% over three chemical steps without isolation of intermediates).

The reactivity of a thiazole can be summarized as follows:

Thiazoles are a class of  related to with a common thiazole . Thiazoles are .
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A series of 4-[2-methyl (or aryl) thiazole-4-yl]-2,6-dimethyl-3,5-diacetyl (or dibenzoyl) 1,4-dihydropyridines were synthesized using a modified Hantzsch reaction involving the condensation of the corresponding aldehyde with acetyl acetone or benzoyl acetone. The preparation of the corresponding aldehydes (2-methylthiazole-4-carboxaldehyde and some 2-arylthiazole-4-carboxaldehydes) was achieved by a simplified protocol of the published synthesis.

An all-L configuration reverse order of peptide bonding possibility for the cell growth inhibitory (PS system) cyclic peptide dolastatin 3 was eliminated by synthesis of thiazole amino acid containing peptide 2. By employing a series (Scheme I) of mixed carbonic anhydride (except for 9 → 11 where DCCI-HBT was used) peptide bond forming reactions with N-Boc protection and a 2,4,5-trichlorophenol active ester cyclization step, cyclic pentapeptide 2 was obtained as a mixture of diastereomers corresponding to the (R)- and (S)-(gln)Thz unit. The thiazole amino acid components were synthesized employing a Hantzsch reaction as the key step (cf. Scheme II). Spectral analysis of the individual (R)- and (S)-(gln)Thz cyclic pentapeptide 2 removed both as structural candidates for dolastatin 3.

Thiazoles are structurally similar to . Like imidazoles, thiazoles havebeen used to give N-S  and .
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Thiazole synthesis - Organic chemistry

AB - A large-scale synthesis of 3,4,5-tri-0-acetyl-2,6-anhydro-L-mannono-and-D-gulonothioamides (5, 6) has been achieved from the corresponding nitriles. The Hantzsch reaction of (5) or (6) with ethyl bromopyruvate afforded the expected thiazoles (7.8) only in a low yield along with furan derivatives (9-11), the formation of which is rationalized by an acid-catalysed rearrangement-elimination process. The some Hantzsch reaction in the presence of barium carbonate yielded hydroxythiazolines (16,17). Attempted dehydration of (16) or (17) with trifluoroacetic anhydride or trifluoroacetic anhydride/pyridine resulted in the formation of pent-1′-enopyranosylthiazoles (18-20). Deprotected thioamides (24,25) furnished with ethyl bromopyruvate thiazoles (27,28). The obtained thiazole esters (7,8, 18-20. 27,28) were transformed into new tiazofurin analogues (12, 13, 21- 23).

Hantzsch thiazole synthesis Topics - Revolvy

The amino atom can be to create athiazolium cation; thiazolium salts are catalystsin the and the . Thiazoledyes are used for dying .

Synthesis and Characterization of Novel 1,3-Thiazole …

The interaction of small molecule compounds with specific human proteins, such as enzymes, receptors or ion channels, is one of the fundamental principles upon which the discovery of new medicines is based. Advantages of low molecular weight drugs include the potential for oral bioavailability, efficient tissue (e.g. brain) penetration and low cost of manufacture, among others. The vast majority of low molecular weight drugs are heterocyclic compounds, often comprising several connected heterocyclic rings. This is not surprising considering the propensity of heteroatoms within drug scaffolds to form reversible interactions (electrostatic, H-bonds etc.) within the active sites of proteins, thereby exerting a modulatory effect. High-throughput screening is one of the most common and effective methods to identify small molecule compounds with activity against the target protein of interest. Invariably, however, the initial hit structure identified in a screening campaign exhibits relatively low potency and selectivity for the target protein, in addition to sub-optimal physicochemical (drug-like) properties. Therefore, the development of new synthetic chemistry methods for the rapid and efficient generation of analogues for in vitro testing is critical for the hit-to-lead optimization of screening hits. Accordingly, we have established a research program focused on developing automated flow chemistry methods to rapidly access complex, drug-like compounds from readily available precursors. More specifically, we are developing highly efficient flow chemistry methods that combine multiple chemical transformations into single, continuous processes. Advantages of this technology include optimal heat transfer, enhanced reagent mixing, precise reaction times, small reaction volumes, and the ability to conduct multistep reactions in a single, unbroken microreactor sequence. Thus, flow processes are safe, environmentally friendly and cost effective on a manufacturing scale. To demonstrate the utility of flow synthesis we have previously reported the continuous flow preparation of bis-substituted 1,2,4-oxadiazoles, functionalized imidazo[1,2-a] heterocycles, pyrrole-3-carboxylic acid derivatives, and 5-(thiazol-2-yl)-3,4-dihydropyrimidin-2(1H)-ones. We now report methodology for consecutive heterocycle formation reactions to access 2-(1H-indol-3-yl)thiazoles, privileged scaffolds with demonstrated biological activity, using an uninterrupted continuous flow microreactor sequence. In this unique continuous process, sequential thiazole formation, deketalization and Fischer indole synthesis provides rapid and efficient access to novel 2-(1H-indol-3-yl)thiazole (indolylthiazole) derivatives 1. These structures, which are generated from β-ketothiazoles 2 and prepared thioamide 3 (), are formed cleanly and without isolation of intermediates.

Thiazole - Infogalactic: the planetary knowledge core

Indoles constitute a ubiquitous structural motif present in a broad range of biologically active small molecules and natural products. These heterocycles are present in investigational and approved drugs such as Tadalafil, an inhibitor of phosphodiesterase 5 (PDE5) (). Tadalafil is currently indicated for the treatment of both erectile dysfunction (Cialis®) and pulmonary arterial hypertension (Adcirca®). Indolylthiazole derivatives also constitute a large family of medicinally significant compounds displaying a wide range of pharmacological properties. For example, the camalexin class of natural products has received much attention in recent years because of both its antifungal and antiviral activity (). In addition, closely related thiazolyl indolequinones, such as the natural product BE 10988, have been identified as potent topoisomerase II inhibitors and have consequently been shown to possess promising anticancer activity (). Due to this broad spectrum of therapeutic areas, methods for the high-throughput synthesis of connected heterocyclic derivatives, like the indolylthiazoles, are of significant interest.

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