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Francis Crick Astonishing Hypothesis Pdf Download
Who better than James Watson to lead a guided tour of DNA? When he and his English colleague, Francis Crick, discovered the double helix structure of the DNA molecule in 1953, little could they imagine that a mere 50 years later scientists would be putting the finishing touches on a map of the human genome. In this magisterial work, Watson, who won the Nobel Prize with Crick for their discovery, guides readers through the startling and rapid advances in genetic technology and what these advances will mean for our lives. Watson covers all aspects of the genome, from the layout of four simple bases on the DNA molecule through their complex construction into genes, then to the mechanisms whereby proteins produced by genes create our uniquely human characteristics-as well as the genetic mutations that can cause illnesses or inherited diseases like Duchenne muscular dystrophy and Huntington's disease. Watson may have mellowed a little over the years since he displayed his youthful brashness in The Double Helix, but he still isn't shy about taking on controversial subjects. He criticizes biotech corporations for patenting genes, making diagnostic medical procedures horribly expensive and damping further basic research. He notes that while China and other countries with large populations to feed have eagerly grasped the potential of genetically modified foodstuffs, America squandered $100 million on a recall of taco shells and the genetically modified corn used in them. He pleads passionately for the refinement and widespread use of prenatal genetic testing. Watson will probably provoke the most controversy with his criticism of scientists, corporations and government funding sources for their avoidance of important areas of research-notably the genetics of skin coloration-for political reasons. Every reader who wants to understand their own medical future will want to read this book.
What makes DNA different from hordes of competitors purporting to help readers understand genetics is that it is written by none other than James Watson, of Watson and Crick fame. He and his co-author Andrew Berry have produced a clear and easygoing history of genetics, from Mendel through genome sequencing. Watson offers readers a sense of immediacy, a behind-the scenes familiarity with some of the most exciting developments in modern science. He gleefully reports on the research juggernaut that led to current obsessions with genetic engineering and cloning. Aided by profuse illustrations and photos, Watson offers an enthusiastic account of how scientists figured out how DNA codes for the creation of proteins--the so-called "central dogma" of genetics. But as patents and corporations enter the picture, Watson reveals his concern about the incursions of business into the hallowed halls of science. After 1975, DNA was no longer solely the concern of academics trying to understand the molecular underpinnings of life. The molecule moved beyond the cloisters of white-coated scientists into a very different world populated largely by men in silk ties and sharp suits. In later chapters, Watson aims barbs at those who are concerned by genetic tinkering, calling them "alarmists" who don't understand how the experiments work. It is in these arguments that Watson may lose favor with those whose notions of science were born after Silent Spring. Nevertheless, DNA encompasses both sides of the political issues involved in genetics, and Watson is an enthusiastic proponent of debate on the subject.
The Astonishing Hypothesis by Francis Crick
On April 25, 1953, James Watson and Francis Crick published their groundbreaking discovery of the double helix structure of DNA, the molecule essential for passing on our genes and the "secret of life." But their crucial breakthrough depended on the pioneering work of another biologist--Rosalind Franklin. She would never know that Watson and Crick had seen a crucial piece of her data without her permission. This was an X-ray image, "Photo 51," that proved to be a vital clue in their decoding of the double helix. 50 years later, NOVA investigates the shocking truth behind one of the greatest scientific discoveries and presents a moving portrait of a brilliant woman in an era of male-dominated science. Sadly, Franklin never lived to see her vital role in the discovery vindicated. While Watson and Crick went on to win the Nobel Prize in 1962, Franklin died in 1958, at 37, from ovarian cancer; and the Nobel is not awarded posthumously. Hear the inside story from Maurice Wilkins, the colleague who showed her crucial x-ray to Watson; Raymond Gosling, Franklin's Ph.D. student with whom she made Photo 51; and Nobel Prize winner Sir Aaron Klug, Franklin's last collaborator, who shows new evidence of just how close Franklin came to making the vital double helix discovery herself.
Another popularization of the Human Genome Project, this one has the distinction of being the first published as an anthology, and among its contributors are some leading scholars, scientists, and social critics. The three parts of the book present essays covering topics in "History, Politics, and Genetics," "Genetics, Technology, and Medicine," and "Ethics, Law, and Society." Some of the essays are quite provocative, especially editor Kevles's "Out of Eugenics: The Historical Politics of the Human Genome" () , Dorothy Nelkin's "The Social Power of Genetic Information", Ruth Schwartz Conan's "Genetic Technology and Reproductive Choice", and James D. Watson's "A Personal View of the Project." Still, there is a good deal of substantive overlap among the essays and, while the discussions by experts are more sophisticated and specialized than those appearing in other books, little new information is presented for general readers. Public libraries with either Jerry Bishop and Michael Waldholz's Genome ( LJ 7/90) or Robert Shapiro's The Human Blueprint ( LJ 9/1/91) do not need this title, but academic libraries should consider it.
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