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Bacterial Endotoxin - Textbook of Bacteriology
FIGURE 8-16 Steps involved in the synthesis of nitric oxide ([NO] see text for details). cGMP = cyclic guanosine monophosphate; NMDA = N-methyl-D-aspartic acid; nNOS = nitric oxide synthase isoform I.
1. b-endorphin: The pre-propeptide, pre-proopiomelano-cortin, is synthesized in rough endo-plasmic reticulum of neurons in the anterior pituitary, in the intermediate lobe of pituitary, and in the arcuate nucleus of hypotha-lamus. Removal of a signal peptide from the pre-propeptide within the rough endoplasmic reticulum results in the generation of the propeptide proopi-omelanocortin, which is then transported to the Golgi apparatus where it is packaged into vesicles. These vesicles are transportevd to the axon terminal by fast axonal transport. Further proteolytic processing in the terminal results in the generation of the active peptides, adrenocorticotropic hormone (ACTH) and P-lipotropin. P-lipotropin is further cleaved into y-lipotropin and P-endorphin (31-amino acid C-terminal fragment). The term "endorphin" refers to a substance that has morphine-like properties. P-endorphin-containing neurons are located in the hypothalamus and send projections to periaqueductal gray (PAG) and noradrenergic cells in the brainstem.
Statistical Techniques | Statistical Mechanics
Synthesis and Removal. In the periphery, histamine is synthesized in mast cells. Histamine circulating in the blood does not cross the blood-brain barrier. Brain cells synthesize their own histamine from histidine, which enters the brain by active transport. Histidine is then decarboxylated by histidine decarboxylase to form histamine. Histamine is metabolized by two enzymes—histamine methyltransferase and diamine oxidase (histaminase)—to organic aldehydes and acids.
ChemInform Abstract: Synthesis and Reactions of …
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