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“Diversity and biosynthesis of compatible solutes in hyper ..

C. Neves, M. S. da Costa & H. Santos
Applied and Environmental Microbiology, 71,8091-8098 (2005).

Protection against IR by UFs and Compatible Solutes of Hyperthermophilic Archaea
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In this study, we investigated the role played by the compatible solutes found in two IR-resistant thermophilic bacteria, R. xylanophilus (D10 6kGy) and R. radiotolerans (D10 10kGy), and two IR-resistant hyperthermophilic archaea, P. furiosus (D10 3kGy) and T. gammatolerans (D10 6kGy). We showed that under aerobic conditions, compatible solutes accumulated by thermophilic bacteria confer IR resistance to enzymes in vitro and that radioprotection is mitigated by the presence of both trehalose andMn2+. With regard to hyperthermophilic archaea, the anaerobic environment contributes to their IR resistance, which was the most significant factor for protection of enzymes in vitro.

ASMscience | The Physiological Role,

An overview of the role and diversity of compatible solutes in Bacteria and Archaea.
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M. S. da Costa, H. Santos & E. A. Galinski
Advances in Biochemical Engineering Biotechnology, 61, 117-153 (1998).

Radiation-resistant bacteria have garnered a great deal of attention from scientists seeking to expose the mechanisms underlying their incredible survival abilities. Recent analyses showed that the resistance to ionizing radiation (IR) in the archaeon Halobacterium salinarum is dependent upon Mn-antioxidant complexes responsible for the scavenging of reactive oxygen species (ROS) generated by radiation. Here we examined the role of the compatible solutes trehalose, mannosylglycerate, and di-myo-inositol phosphate in the radiation resistance of aerobic and anaerobic thermophiles. We found that the IR resistance of the thermophilic bacteria Rubrobacter xylanophilus and Rubrobacter radiotolerans was highly correlated to the accumulation of high intracellular concentration of trehalose in association with Mn, supporting the model of Mn2+-dependent ROS scavenging in the aerobes. In contrast, the hyperthermophilic archaea Thermococcus gammatolerans and Pyrococcus furiosus did not contain significant amounts of intracellular Mn, and we found no significant antioxidant activity from mannosylglycerate and di-myo-inositol phosphate in vitro. We therefore propose that the low levels of IR-generated ROS under anaerobic conditions combined with highly constitutively expressed detoxification systems in these anaerobes are key to their radiation resistance and circumvent the need for the accumulation of Mn-antioxidant complexes in the cell.

Compatible solute influence on nucleic acids: ..

Diversity and biosynthesis of compatible ..
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Organic solutes inRubrobacter xylanophilus ..
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