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Developmental Origins of Health and Disease (DOHaD)
The transcension hypothesis proposes that a universal process of evolutionary development guides all sufficiently advanced civilizations into what may be called "inner space," a computationally optimal domain of increasingly dense, productive, miniaturized, and efficient scales of space, time, energy, and matter, and eventually, to a black-hole-like destination.
Fetal origins of adult diabetes "According to the fetal origin of adult diseases hypothesis, the intrauterine environment through developmental plasticity may permanently influence long-term health and disease. Therefore, intrauterine growth restriction (IUGR), due either to maternal, placental, or genetic factors, may permanently alter the endocrine-metabolic status of the fetus, driving an insulin resistance state that can promote survival at the short term but that facilitates the development of type 2 diabetes mellitus and metabolic syndrome in adult life, especially when the intrauterine nutrient restriction is followed by a postnatal obesogenic environment."
Epigenetic epidemiology of the developmental origins hypothesis
Remember that people who don't take good care of themselves and eventually can't walkmay have subacute combined degeneration of the cord -- and pay with their lives(AMFJP 30: 47, 2009.)* Future pathologists: The same histologic and clinical picture may be seenin copper deficiency ("Are you taking a lot of zinc to prevent colds?") andin nitrous oxide abuse.
In their series using their instrument "to screen for autism and otherdevelopmental delays", 10479 babies were screened and after the false-positives werereclassified, only32 got a diagnosis autism or autism-spectrum disorder -- much lower than the activist claims --and some remitted without any intervention.
The developmental origins of health and disease: …
Fetal growth. "Recent epidemiological and experimental studies show that abnormal fetal growth can lead to serious complications, including stillbirth, perinatal morbidity and disorders extending well beyond the neonatal period. It is now clear that the intrauterine milieu is as important as genetic endowment in shaping the future health of the conceptus. Maternal characteristics such as weight, height, parity and ethnic group need to be adjusted for, and pathological factors such as smoking excluded, to establish appropriate standards and improve the distinction between what is normal and abnormal. Currently, the aetiology of growth restriction is not well understood and preventative measures are ineffective. Elective delivery remains the principal management option, which emphasizes the need for better screening techniques for the timely detection of intrauterine growth failure."
The hypothesis proposes influences cause permanent changes in embryo/fetus, low birth weight, predisposition to chronic disease in adult life. Malnutrition in utero affects brain development, "low birth weight" or intrauterine growth restricted babies fare less well on measures of mental development in later life studies compared low birth weight babies (
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Fetal origins hypothesis - Wikipedia
What is needed now is to update and further constrain such ideas within a model of universal evolutionary development, a model that contrasts a small subset of statistically predictable developmental processes with the apparently much larger set of unpredictable evolutionary experiments occurring within the universe, and perhaps, an understanding of our universe as a finite system engaged in a developmental cycle within a multiversal environment (Smolin 1994).
25/01/2006 · Abstract
Only a special subset of biological change, perhaps something less than 5% at the genetic level, to a first approximation, is what we call developmental.
Home - International Society for Development Origins …
Today's historians say a generation of mothers needsan apology: Lancet 379: 1292, 2012.) In the early 1970's, it was all the fault of "the schizophrenogenic father"instead; as with the "S-mother", evidence was "anecdotal" (i.e., the biological parents of crazy people act screwy themselves; stress sometimes precipitates symptoms) and "based on sound theory" (i.e., "all people are born the same", the left-wing/Skinnerian ideology of the day).
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This theory, now called "developmental origins of health and disease" (DOHAD or DOHaD) and also previously Fetal Origins Hypothesis, is based on the early statistical analysis carried out by David Barker (1938 - 2013) of low birth weight data collected in the early 1900's in the south east of England which he then compared with these same babies later health outcomes. The theory was therefore originally called the "Barker Hypothesis" and has recently been renamed as "fetal origins" or "programming". Several origins have been suggested including: fetal undernutrition, endocrine (increased cortisol exposure), genetic susceptibility and accelerated postnatal growth.
Autophagy in Human Health and Disease — NEJM
Pathik D Wadhwa, Claudia Buss, Sonja Entringer, James M Swanson Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin. Reprod. Med.: 2009, 27(5);358-68
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