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Design and synthesis of conjugated polymers …
This thesis details our progress in the development of synthetic routes which provide access to new classes of conjugated polymers that contain dissimilar side chains that segregate or dissimilar conjugated blocks which phase separate, and summarizes our initial attempts to characterize these materials.
In general, cationic liposomes are not good enough for effective gene therapy because of their potential cytotoxicity and low transfection efficiency [-]. Therefore, it is significantly important to develop novel nontoxic cationic systems with both effective gene transfection ability and good safety.
Design and Synthesis of n-Type Conjugated Polymers …
The design of amphiphilic structures provides additional opportunities for side chains to influence the molecular packing and electronic properties of conjugated polymers.
The initial PPEs in this study have different lengths of alkoxy side chains, and both regioregular and regiorandom analogs are synthesized and characterized for comparison.
Design and synthesis of conjugated polymers (Book, …
However, there still exist numerous and barriers for polymer-based vehicles to achieve ideal transfection efficiency. For transfection, polymeric nanoparticles have no structure as magic as viruses to enter cells and just depend on the unpredictable endocytosis. Thus on one hand more detailed information about the endocytosis mechanism obtained by varying technical methods is needed to increase the entrance into the cells. On the other hand, the size, surface potential and N/P ratio (ratio of nitrogen of polymer to phosphate of DNA) were deeply investigated and some targeting groups like nuclear localization signal were integrated to the nanoparticles. Morover, the escape of nanoparticles from the organelle and DNA from the complexes is one of the key elements influencing the transfection efficiency. For example, particular interest was garnered by PEI mainly for its organelle-escape units. Another big problem for polymeric nanoparticles is the cytotoxicity, which results from poor biodegradability. So the degradable moieties have been incorporated into polymer, such as coating with human serum albumin, dextran, PEG and so forth. Out of these, the specific hurdle for transfection is that polymeric nanoparticles are foreign materials whose invasion will lead to the immune response by the body. The most effective solution is PEGylation, which help avoid the clearance of the reticuloendothelial system. Many researchers are dedicated to devising polymer-based vehicles for exogenous gene transfection and great efforts have been made for gene transfection .
As the polymers arouse more attention of the researchers, more and more new polymeric carriers have been developed for gene transfer. Some typical polymeric carriers are listed in Table and at the same time many other polymeric carriers such as polypeptide and polyphosphoester have also been reported [-].
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Design and synthesis of conjugated polymers
As known, liposomes have the distinct advantages of being both nontoxic and biodegradable because they are composed of naturally occurring substances. Liposomes have been shown to provide stable encapsulation for various molecules like gene, which can protect DNA against enzymatic degradation as well as facilitate cellular uptake and endosomal escape, leading to effective gene transfer. They have possessed not only the excellent biocompatibility and low immunogenicity, but also the ability to deliver large pieces of DNA with well defined physicochemical composition and ease of handling and preparation. Furthermore, they have potential to transfect all kinds of tissue and cell types [-]. An upsurge of global interest in developing efficient cationic lipids for gene delivery was therefore witnessed in recent years [-].
Design and Synthesis of Conjugated Polymers: …
Description :A concise and practical overview of the most important modern synthetic aspects of conjugated polymers and carbon materials, including their properties and applications. Well structured, this book sum...
Design And Synthesis Of Conjugated Polymers Full …
Poly-L-lysine (PLL) is a kind of natural and biocompatible polypeptide with excellent pDNA condensation capacity and one of the cationic polymers firstly used for gene delivery [-]. However, the high cytotoxicity and the low transfection efficiency of PLL severely limit its wide application in gene delivery [-].
A Review of “Design and Synthesis of Conjugated Polymers”
Description :After introducing the subject of conjugated polymers, the thesis has three sections each containing a literature survey, results and discussion, conclusions, and experimental methods on the following:...
Design and Synthesis of Conjugated Polymers by …
Chemical vectors for gene delivery based on only one kind of pure materials, such as lipid or chitosan, have not only their special advantages but also their intrinsic deficiencies which are difficult to resolve. To improve the transfection efficiency and reduce the cytotoxicity, many researchers have focused on combining two or more kinds of materials to enhance the transfection efficiency and at the same time avoiding the side effects to the cells . Dendron-bearing lipids with PAMAM G1 designated as DL-G1-2C18 have been synthesized. In spite of less efficient cellular uptake of the lipoplexes, they generated free pDNA molecules in the cytosol more effectively than other lipoplexes did .
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