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Stimulants make depression worse and serotonin makes ADHD worse.

These secondary complaints, caused by the corticosteroids and other products that lower serotonin levels, may then be treated with selective serotonin reuptake inhibitors or psycho-stimulants (that are known to indirectly increase serotonin levels).

Sahelian's supplements to raise low serotonin levels? A.

To understand what is, we must know what looks like, and neuroscience, to date, has not characterized the optimal brain state, nor how to even assess for it. In a review of serotonin theories of depression, turn the paradigm on its head and conclude:

Is there a blood test for serotonin level ? A.

Are both of these due to a huge influx of Serotonin followed by the absence of?

This is very difficult to answer since levels of serotonin in brain tissue or other parts of the body are impossible to measure accurately, and each person has a different way to absorb and metabolize the various substances in the herb.

Now, research headed up by neuroscientists David Gurwitz and Noam Shomron of Tel Aviv University in Israel supports recent thinking that rather than a shortage of serotonin, a lack of synaptogenesis (the growth of new synapses, or nerve contacts) and neurogenesis (the generation and migration of new neurons) could cause depression. In this model lower serotonin levels would merely result when cells stopped making new connections among neurons or the brain stopped making new neurons. So, directly treating the cause of this diminished neuronal activity could prove to be a more effective therapy for depression than simply relying on drugs to increase serotonin levels.

John's wort off and on for quite a while to alleviate depression.

Below is the biosynthesis of dopamine and serotonin as well as the see-saw effect in action.

Among other findings, there are abundant data relating low serotonin activity--as measured by low cerebrospinal fluid 5-hydroxyindolacetic acid, and a blunted response of prolactin to fenfluramine--to impulsive behavior.

Further studies will be needed to see if this effect of tryptophan has consequences for the effectiveness of dieting as means of weight control.

Aggression: the testosterone-serotonin link.
Be'er Yaakov Mental Health Center, Magen Prison, Ramleh, Israel.

However, lowered serotonin levels may result in depression, aggression and other psychological conditions.
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Serotonin and depression | The BMJ

we propose that depressed states are high serotonin phenomena, which challenges the prominent role the low serotonin hypothesis continues to have in depression research (Albert et al., 2012). We also propose that the direct serotonin-enhancing effects of antidepressants disturb energy homeostasis and worsen symptoms. We argue that symptom reduction, which only occurs over chronic treatment, is attributable to the compensatory responses of the brain attempting to restore energy homeostasis.

Low Serotonin Levels Don't Cause Depression

The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin.

Serotonin, depression, and aggression: The problem of brain energy

Thirty rats were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin after intraperitoneal injections of pyridoxine HCl during 20 days and a single dose of BHT.

Is the Link Between Depression and Serotonin a Myth? - …

The action of these compounds is fairly familiar. SSRIs increase available levels of serotonin, sometimes referred to as the feel-good neurotransmitter, in our brains. Neurons communicate via neurotransmitters, chemicals which pass from one nerve cell to another. A transporter molecule recycles unused transmitter and carries it back to the pre-synaptic cell. For serotonin, that shuttle is called SERT (short for “serotonin transporter”). An SSRI binds to SERT and blocks its activity, allowing more serotonin to remain in the spaces between neurons. Yet, exactly how this biochemistry then works against depression remains a scientific mystery.

Depression: Dopamine vs. Serotonin: Which Is More …

Levels of TBARS and 5-HTP increased considerably in all vitamin- and/or BHT-treated groups, and serotonin increased partially only in B(6) with or without BHT-treated groups compared with control group.

Serotonin, depression, and aggression - The problem …

A lot of people diagnosed as ADHD get thrown towards Bipolar/Depression because their meds were "failing".

They say to avoid caffeine/energy drinks/coffee with your ADHD meds because they act as a minor ADHD med, further increasing dopamine and destroying the serotonin leading to horrible crashes.

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