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Custom Oligos, Custom Synthesis Service - Sigma …

siRNA, phosphorothioates), Morpholinos generally do not cause degradation of their RNA targets; instead, they block the biological activity of the target RNA until that RNA is degraded naturally, which releases the Morpholino.

Oligos are synthesized on the day you order, and delivered to you on the next business day.

A group of degenerate oligonucleotides contain related sequences withdifferences at specific locations. These are used simultaneously in thehope that one of the sequences of the oligonucleotides will be perfectlycomplementary to a target DNA sequence.

When entering your oligo, select the Duplex option on the order form

We provide oligo synthesis services with international delivery including  purification. For custom and modification, please contact us.

One common use of degenerate oligonucleotides is when the amino acid sequenceof a protein is known. One can reverse translate this sequence todetermine all of the possible nucleotide sequences that could encode that aminoacid sequence. A set of degenerate oligonucleotides would then be producedmatching those DNA sequences. The following link will take you to aprogram that will perform a reverse translation.

When ordering degenerate oligonucleotides, you just let the company know thatyou want a mixture of nucleotides added at a specific position using the codebelow. By adding the mixture, oligos will incorporate one of the bases,leading to a mixture of oligonucleotides.

Oligo Modifications - Integrated DNA Technologies - …

The order acceptance time and the lead-time is different for orders placed by e-mail, or on Saturdays, Sundays and holidays.

Punctate fluorescence usually indicates that the oligo is trapped in endosomes, so ignore punctate spots and look for the diffuse fluorescence.

For actual experiments delivering your custom-sequence Morpholino with Endo-Porter you generally need a concentration of only 1 to 5 microMolar for effective steric blocking of most mRNAs.

Though Morpholino oligos are much more soluble than other non-ionic structural types (such as PNAs), some Morpholinos with high G content (>30%) do have limited solubility.

SensaChem offers customized resources and solutions for organic synthesis, process research & development, combinatorial synthesis, cGMP synthesis, and manufacturing.

Each oligo you order will be QC'ed by mass spectrometry to guarantee you receive a quality certified product, everytime.
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repair with a DNA donor oligo; ..

Your research will benefit from our 35 years as the leader in DNA, RNA, and LNA oligonucleotide synthesis. MCRC pioneered the use of MALDI-TOF mass spectrometry as a quality assurance measure; a technique that has become the gold standard for the industry. We remain committed today to providing the highest quality products researchers around the globe.

Sigma-Genosys Procedure for Sending Custom Oligo …

Each morpholine ring suitably positions one of the standard DNA bases (A,C,G,T) for pairing, so that a 25-base Morpholino oligo strongly and specifically binds to its complementary 25-base target site in a strand of RNA via Watson-Crick pairing.

Sigma-Genosys Procedure for Sending Custom Oligo Orders via Email

For your research needs, we provide modifications from one to seventeen in a single oligo and can add more from 50 nanomole to 15 micromole scale of synthesis and in amounts from 1 ODU to 1 gram and beyond. You can order from 400 modifications including:

Oligo Ordering - Biochemistry and Molecular Biology

administration or enter cells in tissues surrounding local injections; they are also the most convenient antisense oligos for use in cell cultures or explants, as they do not require any additional agent for cytosolic delivery.

A Morpholino oligo is radically different from natural nucleic acids, with methylenemorpholine rings replacing the ribose or deoxyribose sugar moieties and non-ionic phosphorodiamidate linkages replacing the anionic phosphates of DNA and RNA.

click on Custom DNA Oligos (under Custom Synthesis) ..

Whether you need dual-labeled FRET probes and primers or 100 or 100,000 custom oligos for microarray applications, Biosearch can meet your most stringent and exacting synthesis, purification, QA/QC and documentation specifications.

Peptide Synthesis: Custom peptide synthesis services …

Place your order through this website or by email or by calling us to discuss the specific technical challenges your research faces and the custom oligos we will synthesize just for you.

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