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and nucleotide analog from the mg to kg scale in a Custom Synthesis
Armed with superb chemistry problem solving skills, our teams of well-trained synthetic chemists work closely with our clients in a concerted effort towards the objectives of client-directed projects. In this typically full-time-equivalent (FTE) arrangement, the client sends us the target structures, and we perform the route design and deliver the molecules. Whether the compounds are designed for the discovery of a novel drug, or a crop protection product, or a performance chemical, a close interaction with timely communications between the clients and our teams is the key to ensure that the right molecules are synthesized and the irrelevant molecules are dropped. The access to a central stock room of >20,000 reagents allows rapid start of the synthesis, and our dedicated logistics and compound management teams ensure expedient delivery of the compounds to the right location and in the right format for evaluations. We work with our clients to streamline the workflow to maximize productivity and to shorten the design-synthesis-evaluation cycle time.
VioGen Biosciences is a research and development organization, specializing in custom chemical synthesis, contract research and process development. Our experienced and knowledgeable chemists have worked for many years in the field of custom synthesis, with extensive academic and industrial backgrounds specializing in small organic molecule development. Our team can under take all of the usual organic reactions that are required in synthetic medicinal chemistry. VioGen Biosciences offers a full range of services in custom organic synthesis including: process development, route scouting and selection, kinase focused libraries, heterocyclic building blocks, nucleosides and nucleoside phosphoramidites, prodrug synthesis, polymorph screening and stability studies of API and intermediates. Additionally, we offer synthesis of organometallics, boronic acids, trifluoroborates; asymmetric synthesis and chiral separations are offered, ranging from milligram to multigram quantities. We can help your laboratory to develop new chemical entities on an exclusive or non-exclusive basis.
radiolabeling oligo synthesis service - amchemicals
We provide solid phase peptide synthesis to customers from the biomedical, biotechnology and pharmaceutical industry. We maintain high quality standards and technical expertise.
A large number of nucleoside and nucleobase analogues have been synthesized and developed as anticancer, antiviral, antibacterial, and antiparasitic drugs (4-6). Many of these analogues act by intracellular conversion to deoxyribonucleotide analogues, which selectively block DNA replication (because deoxyribonucleotides have no significant metabolic roles other than as DNA constituents). A few of the most prominent of these analogues are shown in Figure 4 and discussed briefly here.
Custom Synthesis of Polyphosphates and …
Because of their negative charge, nucleotides are not readily transported through cell membranes. With most nucleobase or nucleoside drugs, the active form of the drug is a nucleotide analogue— FdUMP in the example under discussion. Thus, in order to use nucleic acid precursors successfully as drugs, the biochemical pharmacologist must be aware of the nucleotide biosynthetic salvage enzymes in target cells (see Salvage Pathways To Nucleotide Biosynthesis), so that a precursor is administered that can be converted to the active nucleotide. One must be concerned also with degradative enzymes. For example, nucleoside phosphorylase can cleave fluorodeoxyuridine to 5-fluorouracil plus deoxyribose-1-phosphate, a reaction that would limit the effectiveness of the drug by decreasing its availability for conversion to the active FdUMP.
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