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A Combinatorial Process for Drug Discovery - …
The role played by chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.
Medicinal chemistry focuses on small organic molecules—encompassing synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, aiming at the discovery and development of new therapeutic agents. This field involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for medicinal products.
Combinatorial chemistry, Drug Discovery Today | …
Combinatorial chemistry used to conceivably develop some of the non-biological derivatives is in itself fundamentally based on the naturally occurring processes; only these processes are systematically used to create new leads in drug discovery.
Exclusive Chemistry Ltd is a chemistry-based company specializing in the design and synthesis of organic compounds for the pharmaceutical, drug discovery, agrochemical and biotechnology industries.
Combinatorial chemistry in drug discovery. - …
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