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The Cholinergic Hypothesis of Age and Alzheimer's …
Pop Sugar, December 2017
"Turmeric is recommended for many patients with inflammatory conditions such as Crohn's disease, ulcerative colitis, autoimmune conditions like psoriasis, rheumatoid arthritis, osteoarthritis, Parkinson's disease, Alzheimer's disease, dementia, and cancers. Curcumin is the compound found in turmeric," said Atlanta-based integrative medicine physician Dr. Bindiya Gandhi. Arguably, the most powerful aspect of curcumin is its ability to control inflammation. "The journal Oncogene published the results of a study that evaluated several anti-inflammatory compounds and found that aspirin and ibuprofen are least effective, while curcumin is among the most effective anti-inflammatory compounds in the world," said Dr. Josh Axe, DNM, CNS, DC, bestselling author of Eat Dirt. "This news should have reached every household in the world after the study was conducted, because inflammation puts people at risk for almost every disease process known to man," he said. You can find turmeric in powder culinary spice form and in its whole root form, as well as in tincture, tablets, and capsules. "A good starting dose for its anti-inflammatory benefits is 400 to 600 mg of standardised powder or curcumin turmeric extract three times a day as tolerated," Dr. Gandhi said.
ALZHEIMER'S DISEASE ("pre-senile dementia", "senile dementia", "old timer's disease", "brain failure", etc.;"a primer for practicing pathologists": Arch.
alzheimer’s disease and cholinergic hypothesis Free essays on ..
In the Baltimore study, atherosclerosis itself was correlated very stronglywith dementia in the absence of Alzheimer's, especially in very old folks(Brain 133: 2225, 2010).
For example, Piracetam has been originally developed to treat chronic neurodegenerative disorders, such as Alzheimer’s disease. Similarly, Noopept an neuroprotective dipeptide has been shown to have significant normalising effects in cognitive deficiency in rats. Nootropics exert their effects via different systems in the body and cholinergic system is one of them.
Revisiting the cholinergic hypothesis in Alzheimer's ..
AD has been associated with the abnormalities of several neurotransmitter systems in the brain. It is well-known that patients with AD have seriously low levels of acetylcholine neurotransmitter. Furthermore, degeneration of the cholinergic system underlies memory loss associated with AD. Therefore, a number of pharmacological treatments have focussed on delaying and minimising cholinergic neurodegeneration in order to maintain cognitive function. This is sometimes called “cholinergic hypothesis” of cognitive dysfunction.
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