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Centre for Synthesis and Chemical Biology (CSCB)
The second main focus of my research is based on thesynthesis and analysis of metal based anti-cancer drugs. The search foreffective anti-cancer drugs is still a very important task in modern research,especially in chemistry, as a result of the wide variety of tumor types andproblems of toxicity associated with conventional cancer therapies. A possiblemetal for incorporation within organometallic anti-cancer agents is germaniumand one advantage of organogermanium compounds is that they combine cytotoxicactivity with a stimulation of the immune system with almost no detectable signof toxicity. Research in the area of titanium-based complexes as potentialanti-cancer drugs showed impressive results over the last 5 years and webelieve there is still scope for further improvements. The idea of thisresearch is to devise and evaluate new organic and organometallic syntheticroutes to allow access to biologically interesting anti-cancer agents.
Box 141, Gebze, 41400, Kocaeli, Turkey), AC(School of Chemistry, Centre for Synthesis and Chemical Biology (CSCB), University of Dublin, Trinity College, Dublin, Ireland), AD(Gebze Institute of Technology, Department of Chemistry, P.O.
Centre for Synthesis and Chemical Biology
As a postdoctoral fellow I was working on highly substitutedTitanocenes as a novel class of metal based anti-cancer drugs (see). This research included the synthesis of biologically activeorganometallic compounds and their organic precursors, in vitro studies of thecytotoxic potential in form of MTT-based assays[3-5,7,12-14,16] andthe evaluation of the biological and medicinal properties (mechanistic, and studies) in cooperation with ourinternational collaboration partners[1,2,6,8-11].
The Taoiseach was speaking in University College Dublin, where he opened the university's Centre for Synthesis and Chemical Biology (CSCB) building.
Centre for Synthesis and Chemical Biology (CSCB) - …
What do organic synthesis, mechanistic enzymology, structural biology and glycoscience have in common? They all span chemistry and biology, benefit from and contribute to multidisciplinary approaches, and were up for discussion at a recent symposium in Dublin.
Box 141, Gebze, 41400, Kocaeli, Turkey), AE(School of Chemistry, Centre for Synthesis and Chemical Biology (CSCB), University of Dublin, Trinity College, Dublin, Ireland), AF(School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK), AG(School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK), AH(Department of Chemistry, University of Durham, Durham, DH1 3LE, UK), AI(Department of Chemistry, University of Durham, Durham, DH1 3LE, UK), AJ(Department of Chemistry, University of Hull, Kingston-upon-Hull, East Yorkshire, HU6 7RX, UK)
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