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Pittsburgh compound B ([11 C]PiB) ..

The auto-synthesis method was developed for the on-line preparation of amyloid-beta (Aβ) plaques image agent 11C-PIB. A intermediate, 11CH3OTf, made from 11CH3 which was produced from 11CO2 with LAH/THF, was bubbled into 1.0 mg precursor 6-OH-BTA-0 butanone solution in salt-ice condition. The final crude product was then purified though prep-HPLC to get purified product. The human images were obtained in four cases of AD and 1 normal volunteer. The total synthesis process took about 35 minutes. The synthesis yield (EOS) was (25±5)% (not correct), the radiochemical purity over 98%, and the specific activity about 5.55 GBq/μmol. The modified automated preparation of 11C-PIB was verified in producing 11C-PIB of high radiochemical purity and synthesis yield in a short time. The results showed that this promising product could be used in clinical imaging.

11c pib synthesis essay - US IT Placements

T1 - Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis

11c pib synthesis essay - DJ VITALIK

KW - [11C]PIB

N2 - [11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.

AB - [11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.

Radiation Dosimetry of β-Amyloid Tracers 11C-PiB and …

01/12/2010 · Thiol-terminated polyisobutylene: Synthesis, characterization, ..

The measured modulus is in excellent agreement with an affine network prediction assuming that each MA-PIB-MA chain gives rise to three elastic strands in the network.AB - A new bicomponent conetwork, poly(ethyl acrylate)-linked-polyisobutylene (PEtA-l-PIB), was synthesized by radical copolymerization of equal amounts of telechelic α,ω-dimethacrylic PIB (MA-PIB-MA, Mn/(kg/mol) = 11.2, Mw/Mn = 1.12, and MA/chain = 2.0) obtained via quasi-living carbocationic polymerization and ethyl acrylate in 10% solution for each component in a common solvent, tetrahydrofuran, followed by extraction and drying.

[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.

C]acetate, [11 C]choline, [11 C]methionine and [11 C]PIB ..
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