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H., His6 tag-assisted chemical protein synthesis.
R., Activity-Based Protein Profiling Reagents for Protein Arginine Deaminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe.
Chiral organoborane reagents, in particular [1,3,2]-oxazaborolidines, have been extensively studied and applied as efficient Lewis acid catalysts to a wide range of asymmetric transformations. The B–H oxazaborolidine-borane complexes are frequently reported as convenient catalysts for enantioselective borane reduction of prochiral ketones, imines and oximes, since they are readily prepared from the corresponding aminoalcohols and either borane-THF or borane-DMS complexes., However, the extreme sensitivity of these reagents to atmospheric moisture makes them difficult to isolate and purify. Consequently, they are prepared in situ prior to use in asymmetric reductions. Moreover, B–H oxazaborolidines can form dimers and other species which can affect the nature of catalyst. Impurities present in the catalyst may lead to irreproducible results. On the other hand, B-substituted oxazaborolidines show excellent synthetic utility due to their highly reproducible enantioselectivity, but require careful purification procedures to eliminate traces of boronic acid and their esters. Moreover, the commercially available reagents are expensive, moisture sensitive and unstable during extended storage. Accordingly, the design of new stable, easily available and efficient catalysts is always a challenging task in synthetic organic chemistry.
α-Halo boronic esters in asymmetric synthesis - …
Introduction Borateester formation of a carbohydrate's diol functions has been used for a long time for the synthesis, analysis and separation of carbohydrates.
This thesis describes progress on the application of boronic acids and borate esters as catalysts and reagents in synthetic organic chemistry, focusing on two areas: one-pot enolate formation/aldol reactions and amide bond formation.
α-Halo boronic esters in asymmetric synthesis
R.; Lober, S.; Hubner, H.; Gmeiner, P., Click chemistry on solid phase: parallel synthesis of -benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands.
B., Synthesis of azide-alkyne fragments for click' chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols.
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Synthesis and Application of Borate Ester Bonding …
Margarita Ortiz-Marciales was born in 1943 in Bogotá, Colombia, and obtained her B.S. from Universidad Nacional de Colombia in 1968. She studied at Freiburg and Mainz universities, Germany, for two years with a DAAD fellowship. She received her M.S. from the University of Alabama in Huntsville under Prof. S. McManus supervision in 1973, and her Ph.D. in Organic Chemistry at the University of Alabama-Tuscaloosa in 1979 under the direction of Prof. McManus and Prof. R. Abramovitch. In 1980, she did postdoctoral studies in Prof. G. Larson’s group at the University of Puerto Rico-Río Piedras. She joined the University of Puerto Rico-Humacao in 1981, where she is currently a professor. Her interests are in the development of new synthetic methodologies using boron and silicon compounds for the preparation of important organic intermediates and biologically-active amines.
Chiral Borate Esters in Asymmetric Synthesis. Part 2
Kun Huang received his B.S. degree in 1996 from Sichuan University China. He obtained his Ph.D. in 2006 at Nanjing University, China, working on the asymmetric epoxidation and cyclopropanation of chiral sulfonium ylides. He worked as an advanced synthetic researcher in Wuxi Pharma Tech Co., Ltd, Shanghai, China until he moved to Puerto Rico University in Humacao for his postdoctoral studies with Professor Margarita Ortiz-Marciales on the asymmetric reduction of O-benzyl oximes and ketones catalyzed by spiroborate esters. Later, he had a postdoctoral research position at the chemistry department at Oregon State University where his research was focused on the total synthesis of natural products. Currently, he is a postdoctoral researcher at Peking University in China.
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