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Shikimate Pathway and Aromatic Amino Acid Biosynthesis
The shikimate pathway consists of seven enzymatic reactions whose end product chorismate is the precursor for the synthesis of the aromatic amino acids Phe, Tyr and Trp. In fungi and plants, chorismate is a precursor for many specialised metabolites (i.e. secondary metabolites) that play an important role in the plant's interaction with its environment. The shikimate pathway and aromatic amino acid biosynthesis have been extensively studied in a variety of microorganisms, fungi and plants. Furthermore, the dual involvement of the shikimate and aromatic amino acid biosynthesis pathways in central and specialised metabolism still raises major questions regarding the genes and enzymes involved, and their control, their evolutionary origins and coordinated regulation with genes of associated pathways in response to altered environmental conditions and diverse developmental programs.
Gientka I and Duszkiewicz‐Reinhard W (2009) Shikimate pathway in yeast cells: enzymes, functioning, regulation – a review. Polish Journal of Food and Nutrition Sciences 59(2): 113–118.
Enzymes of the shikimic acid pathway encoded ..
Ding L, Hofius D, Hajirezaei MR et al. (2007) Functional analysis of the essential bifunctional tobacco enzyme 3‐dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants. Journal of Experimental Botany 58(8): 2053–2067.
Chorismate is de novo synthesised from erythrose-4-phosphate, a product of and phosphoenolpyruvate, a product of via the intermediate shikimate in seven reactions.
Shikimic acid pathway - an overview | ScienceDirect …
The steps 2-6 of shikimate biosynthesis pathway (22.214.171.124, 126.96.36.199, 188.8.131.52, 184.108.40.206 & 220.127.116.11 respectively) is carried out by a penta-functional protein called AROM peptide in yeast  and all these activities are annotated to a single protein (TGME49_107040) in Toxoplasma gondii.
Hoffmann L, Besseau S, Geoffroy P et al. (2004) Silencing of hydroxycinnamoy‐coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis. Plant Cell 16(6): 1446–1465.
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1 – The Shikimate Pathway: Biosynthesis of the …
Dal Cin V, Tieman DM, Tohge T et al. (2011) Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. Plant Cell 23(7): 2738–2753.
An outline of the Shikimate Pathway Biosynthesis of the ..
falciparum growth and reversal of it with PABA suggested the specific targeting of shikimate pathway .The presence of shikimate pathway was also demonstrated in T.
Shikimic Acid Pathway | SpringerLink
Maeda H, Shasany AK, Schnepp J et al. (2010) RNAi suppression of arogenate dehydratase1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in Petunia petals. Plant Cell 22: 832–849.
SHIKIMIC ACID PATHWAY - PowerPoint PPT Presentation
Mueller TC, Massey JH, Hayes RM, Main CL and Stewart CN Jr (2003) Shikimate accumulates in both glyphosate‐sensitive and glyphosate‐resistant horseweed (Conyza canadensis L Cronq.). Journal of Agricultural and Food Chemistry 51(3): 680–684.
THE SHIKIMATE PATHWAY | Annual Review of Plant …
Pline WA, Wilcut JW, Duke SO, Edmisten KL and Wells R (2002) Tolerance and accumulation of shikimic acid in response to glyphosate applications in glyphosate‐resistant and nonglyphosate‐resistant cotton (Gossypium hirsutum L.). Journal of Agricultural and Food Chemistry 50(3): 506–512.
Shikimate Pathway | Metabolic Pathway | Biosynthesis
In addition, four enzymes of shikimate pathway namely 3-deoxy-7-phosphoheptulonate synthase, shikimate dehydrogenase, shikimate kinase and aminodeoxy-chorismate lyase (PABA synthetase) were detected in both sensitive and resistant strains of P.
Shikimate Pathway - Download as PDF File ..
Chen Y, Zhang X, Wu W et al. (2006) Overexpression of the wounding‐responsive gene AtMYB15 activates the shikimate pathway in Arabidopsis. Journal of Integrative Plant Biology 48(9): 1084–1095.
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