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Sulphur Amino Acids: Biosynthesis of Cysteine and Methionine

Methionine is synthesized from oxaloacetate. Succinyl-CoA participates and cysteine donates a sulfur group to the molecule. Oxaloacetate is first converted into homoserine as described above in the threonine biosynthetic pathway. Homoserine then has a sulfur attached to the end in two steps and finally methionine is formed by the addition of a methyl group.

Chernyshevskii Saratov State University, Saratov, Russia, and others)Biosynthesis of Cysteine;pp.

The biosynthesis of lysine, methionine and threonine are not, then,controlled as a group.The pathway from aspartate to lysine has 10 steps.The pathway from aspartate to threonine has 5 stepsThe pathway from aspartate to methionine has 7 stepsRegulation of the three pathways also occurs at the two branch points: -Aspartate-semialdehyde (homoserine and lysine) Homoserine (threonineand methionine)The regulation results from feedback inhibition by the amino acid products ofthe branches, indicated in the brackets above. We will consider one important step in the synthesis of this group of 3 aminoacids, namely the step in which homocysteine is converted to methionine,catalyzed by the enzyme : In this reaction, homocysteine is methylated to methionine, and the C1donor is N5-methyl-THF.

Protein Lounge: Biosynthesis of Cysteine in Mammals

These findings explain the absence of identifiable genes in the genome of this organism for the biosynthesis of cysteine and homocysteine.

Topics include cysteine biosynthesis in plants; the structural and functional role of cysteine residues; new cysteine synthesis pathways and their applications; implications for cysteine neurotoxicity; and the protecting groups used to cage cysteine and their applications in biochemical experiments are reviewed.

KEGG PATHWAY: Metabolic pathways - Reference …

These findings explain the absence of identifiable genes in the genome of this organism for the biosynthesis of cysteine and homocysteine.

Read "The biosynthesis of cysteine and homocysteine in Methanococcus jannaschii, Biochimica et Biophysica Acta (BBA) - …
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