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A bilirubin level of more than 85 μmol/l ..
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In chronic, acquiredliver diseases, the serum bilirubin concentration is usually normal until asignificant amount of liver damage has occurred and cirrhosis is present.
It also maintains protein metabolism in its synthesis and ..
(10 year old boy developed jaundice 10 days after starting TMP-SMZ [bilirubin 8.0 mg/dL, AST 80, Alk P 5 times ULN] with rapid resolution; 3 months later a course of TMP alone led to jaundice within 1 week with similar pattern of serum enzyme elevations).
(15 year old girl developed fever, rash and jaundice after third weekly dose of pyrimethamine-sulfadoxine [bilirubin rising from 0.6 to 8.5 mg/dL, ALT 763 U/L, Alk P 669 U/L, atypical lymphocytosis]; patient ultimately died of acute liver failure).
The liver is the site of protein synthesis, ..
(34 year old man with Crohn disease developed fever, rash, atypical lymphocytosis and hepatic failure after 1 day of restarting sulfasalazine, [bilirubin rising from 4.0 to 10.4 mg/dL, AST 1628 U/L, 10% eosinophilia], with apparent beneficial response to prednisone).
(23 year old man developed liver injury arising within 7 days of starting TMP-SMZ [bilirubin rising from 0.8 to 6.9 to 10.3 mg/dL, ALT 1706 U/L], evolving rapidly into acute liver failure and need for transplant).
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This isoform glucuronidates bilirubin IX …
Liver involvement in the sulfone syndrome. Arch Intern Med 1986; 146: 875-7. (49 year old woman developed fever and malaise 2 weeks after starting dapsone [bilirubin 4.5 mg/dL, AST 2540 U/L, ALk P 177 U/L]; rapid response to prednisone in ~4 weeks, review of literature and FDA reports).
are those that measure synthesis of proteins ..
(50 year old woman with rheumatoid arthritis developed anorexia and abdominal pain 11 weeks after starting sulfasalazine; no features of hypersensitivity [bilirubin normal, ALT 1449 U/L, Alk P 230 U/L], resolving within 17 days of stopping).
Bilirubin - urine. Causes, symptoms, treatment Bilirubin - urine
(37 year old man with severe hepatocellular injury [bilirubin 6.9 mg/dL, ALT 1994 U/L, Alk P 271 U/L] starting with rash 2 weeks after starting sulfasalazine, slow to resolve).
Written by Jens Joergen Jaeger and Hanne Hedegaard, Denmark
(19 year old woman developed fever and jaundice 24 days after starting dapsone [bilirubin 9.8 mg/dL, ALT 2745 U/L, Alk P 201 U/L] with signs of acute liver failure, but ultimately spontaneous resolution).
What does it mean - and what is normal in Blood tests
(42 year old man with Crohn disease had onset of rash, fever and abdominal pain 18 days after starting sulfasalazine followed by jaundice and progressive hepatic failure [ALT 3700 U/L, Alk P 619 U/L, bilirubin 18.4 mg/dL], leading to multiorgan failure and death; autopsy showed massive necrosis).
Glossary | Linus Pauling Institute | Oregon State University
(53 year old man with rheumatoid arthritis developed fever, rash, atypical lymphocytes, eosinophilia and low complement levels, similar to serum sickness 2 weeks after starting sulfasalazine [bilirubin 6.0 rising to 8.9 mg/dL, ALT 231 U/L, Alk P 706 U/L], with slow recovery despite corticosteroids).
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