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Jude Medical bileaflet valve prosthesis

AB - Each year, approximately 50,000 aortic valve replacement operations are performed in the United States, but despite decades of development, many of the limitations of aortic valve prostheses remain consequences of the fluid dynamics induced by the replacement valve. We aim to develop detailed fluidstructure interaction (FSI) models of aortic valve prostheses mounted within a ViVitro Systems, Inc. pulse duplicator. Here, we describe numerical methods for simulating FSI with rigid structures, such as the leaflets of a mechanical heart valve, and we present initial three-dimensional simulation studies of the fluid dynamics of a St. Jude Regent bileaflet valve prosthesis.

Jude prosthesis for aortic and mitral valve replacement: A ten‐year experience

N2 - Each year, approximately 50,000 aortic valve replacement operations are performed in the United States, but despite decades of development, many of the limitations of aortic valve prostheses remain consequences of the fluid dynamics induced by the replacement valve. We aim to develop detailed fluidstructure interaction (FSI) models of aortic valve prostheses mounted within a ViVitro Systems, Inc. pulse duplicator. Here, we describe numerical methods for simulating FSI with rigid structures, such as the leaflets of a mechanical heart valve, and we present initial three-dimensional simulation studies of the fluid dynamics of a St. Jude Regent bileaflet valve prosthesis.

Dysfunction of Bileaflet Aortic Prosthesis

OBJECTIVE—To determine the haemodynamic behaviour, at rest and during exercise, of aortic valve pericardial bioprostheses and different sizes of bileaflet prosthesis.
DESIGN—Observational study.
SETTING—Tertiary medical centre.
PATIENTS AND INTERVENTIONS—74 patients (33 women, 41 men; mean age 64 years) in whom 40 pericardial bioprostheses and 34 bileaflet prostheses sized 19, 21, or 23 mm had been implanted to replace aortic valves.
MAIN OUTCOME MEASURES—Doppler echocardiography at rest and at peak exercise, between 12 and 47 months after surgery.
RESULTS—All patients achieved a significant increase in heart rate, systolic blood pressure, and cardiac output with exercise. Transvalvar pressure fall, valve area, and left ventricular systolic and diastolic function indices also underwent significant changes with exercise. Reductions in peak and mean transvalvar pressure, at rest and at peak exercise, were greater in patients with small valves (p
CONCLUSIONS—19 mm and 21 mm aortic prostheses and bioprostheses continue to create significant obstruction, particularly with exercise.


Keywords: small aortic prostheses; haemodynamic variables; exercise

Each year, approximately 50,000 aortic valve replacement operations are performed in the United States, but despite decades of development, many of the limitations of aortic valve prostheses remain consequences of the fluid dynamics induced by the replacement valve. We aim to develop detailed fluidstructure interaction (FSI) models of aortic valve prostheses mounted within a ViVitro Systems, Inc. pulse duplicator. Here, we describe numerical methods for simulating FSI with rigid structures, such as the leaflets of a mechanical heart valve, and we present initial three-dimensional simulation studies of the fluid dynamics of a St. Jude Regent bileaflet valve prosthesis.

Orientation of bileaflet mechanical aortic valve …

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