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Barker’s in utero hypothesis, Biology

Barker was the first to demonstrate that low birth weight infants are at greater risk for developing coronary heart disease in adulthood. He subsequently showed that they are also at greater risk of stroke, high blood pressure and Type-2 diabetes. This led to his hypothesis that malnutrition in the womb and during infancy results in altered programming that permanently changes physiology and metabolism. During his talk at the 2011 Pioneers in Endocrinology Workshop, Barker argued that public health medicine is failing and that its cornerstone should be to protect the health and nutrition of young women before and during pregnancy to prevent chronic disease later in life.

Baker and Bellis expanded their hypothesis.

Armelagos and other bioarcheologists have noted the connection between dental enamel and early mortality for years. For the paper, Armelagos led a review of the evidence from eight published studies, applying the lens of the Barker hypothesis to remains dating back as far as 1 million years.

A fruitful, wrong hypothesis? Response to baker, …

The Barker Hypothesis

Armelagos led a systematic review of defects in teeth enamel and early mortality recently published in Evolutionary Anthropology. The paper is the first summary of prehistoric evidence for the Barker hypothesis - the idea that many adult diseases originate during fetal development and early childhood.

The Barker hypothesis is named after epidemiologist David Barker, who during the 1980s began studying links between early infant health and later adult health. The theory, also known as the Developmental Origins of Health and Disease Hypothesis (DOHaD), has expanded into wide acceptance.

A prime gap is the difference between two successive prime numbers

cummins in baker, c. (2001). common underlying proficiency. cummins in baker, c. (2001). threshold hypothesis. cummins in baker, c. (2001). pair activity.

"The prehistoric data suggests that this type of dental evidence could be applied in modern populations, to give new insights into the scope of the Barker hypothesis," Armelagos says. "Bioarcheology is yielding lessons that are still relevant today in the many parts of the world in which infectious diseases and under-nutrition are major killers."

Until now, teeth have not been analyzed using the Barker hypothesis, which has mainly been supported by a correlation between birth weight in modern-day, high-income populations and ailments like diabetes and heart disease.

Mark C. Baker, Stewart Goetz (eds.) The Soul Hypothesis: Investigations into the Existence of the Soul Published: February 18, 2011. Mark C. Baker …
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